(1118–1149) Genetics, Genomics and Proteomics Poster

Sunday, November 13, 2022

1:00 PM – 3:00 PM Eastern Time

Location: Virtual Poster Hall

All of the relevant financial relationships listed for faculty have been mitigated.

Poster abstract session.

Presentations:

1:00 PM – 3:00 PM Eastern Time

Monocyte Transcriptomic Analysis Uncovers Heterogeneous Gene Expression Profiles in Systemic Lupus Erythematous (SLE) with and Without Subclinical Atherosclerosis
Abstract Poster Presenter: Laurel Woodridge, PhD – UCL
1:00 PM – 3:00 PM Eastern Time

WITHDRAWN
1:00 PM – 3:00 PM Eastern Time

Transcriptome-Wide Association Study of Sjögren’s Disease Risk Alleles Identifies Novel Genes with Altered Expression in Minor Salivary Gland and Other Tissues
Abstract Poster Presenter: Marcin Radziszewski – Oklahoma Medical Research Foundation
1:00 PM – 3:00 PM Eastern Time

Intricate Roles of Low Gene Copy Numbers for Complement C4, C4A Deficiency and HLA-DRB1*03 as Genetic Risk Factors for Myositis, Its Subgroups and Autoantibodies
Abstract Poster Presenter: Danlei Zhou, PhD – Nationwide children's hospital
1:00 PM – 3:00 PM Eastern Time

Short Peripheral Blood Leukocyte Telomere Length in Rheumatoid Arthritis - Interstitial Lung Disease
Abstract Poster Presenter: Pierre-Antoine Juge, MD, PhD – Rheumatology department, Bichat Hospital
1:00 PM – 3:00 PM Eastern Time

Excess of Rare Deleterious Variants Within JAK-STAT Pathway - Related Genes in Patients with Rheumatoid Arthritis Associated Interstitial Lung Disease
Abstract Poster Presenter: Pierre-Antoine Juge, MD, PhD – Rheumatology department, Bichat Hospital
1:00 PM – 3:00 PM Eastern Time

CD4+ Cytotoxic T Lymphocytes (CTL) Are Present in Sjögren’s Disease Minor Salivary Glands and Associate with Markers of Epithelial Cell Damage near Infiltrates
Abstract Poster Presenter: A. Darise Farris, PhD – Oklahoma Medical Research Foundation
1:00 PM – 3:00 PM Eastern Time

Genomics of JAK-STAT Signaling in Venous Thromboembolism
Abstract Poster Presenter: Tue Kragstrup, MD, PhD – Aarhus University
1:00 PM – 3:00 PM Eastern Time

Functional NOTCH4 Variants Increase Notch Signaling and Susceptibility for Systemic Sclerosis
Abstract Poster Presenter: Urvashi Kaundal, PhD – National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)
1:00 PM – 3:00 PM Eastern Time

Unsupervised Clustering Analysis of the Serum Proteome Identifies Systemic Sclerosis Patients with Distinctive Clinical Features
Abstract Poster Presenter: Chary Lopez-Pedrera, PhD – IMIBIC - Reina Sofia Hospital
1:00 PM – 3:00 PM Eastern Time

WITHDRAWN
1:00 PM – 3:00 PM Eastern Time

Integrated High-throughput Proteomics and Machine Learning Analysis in Systemic Lupus Erythematosus Patients Identify Distinctive Clinical Profiles and Novel Biomarkers Related to Cardiovascular Risk and Lupus Nephropathy
Abstract Poster Presenter: Chary Lopez-Pedrera, PhD – IMIBIC - Reina Sofia Hospital
1:00 PM – 3:00 PM Eastern Time

Identification of Novel Molecular Signatures Associated with the Therapeutic Response to DMARDs and TNFi Therapies in Rheumatoid Arthritis Patients Through High Throughput Proteomics
Abstract Poster Presenter: Carlos Perez-Sanchez, PhD – IMIBIC
1:00 PM – 3:00 PM Eastern Time

Integrating Genome and Transcriptome-Wide Associations with Real-World Data to Assess Risk for Leukopenia in Patients Taking Azathioprine
Abstract Poster Presenter: Cecilia Chung, MD, MPH – Vanderbilt University Medical Center
1:00 PM – 3:00 PM Eastern Time

Interaction of LOC100507053, ADH1B, and ADH1C with Alcohol Consumption for Elevated Serum Urate Levels and Gout in People of European Ethnicity
Abstract Poster Presenter: Min Hui Chuah, MBChB – University of Auckland
1:00 PM – 3:00 PM Eastern Time

Ancestry, ACKR1, and Leucopenia in Patients with Systemic Lupus Erythematosus
Abstract Poster Presenter: Vivian Kawai, MD – Vanderbilt University Medical Center
1:00 PM – 3:00 PM Eastern Time

Genome-wide Association Study Identifies Novel Loci for Leukopenia Among TPMT and NUDT15 Normal Metabolizers Taking Azathioprine
Abstract Poster Presenter: Cecilia Chung, MD, MPH – Vanderbilt University Medical Center
1:00 PM – 3:00 PM Eastern Time

Urine Proteomics Implicate Complement C3 and Factor I in Lupus Nephritis Patients with Interstitial Fibrosis and Tubular Atrophy
Abstract Poster Presenter: Shudan Wang, MD, MS – Albert Einstein College of Medicine
1:00 PM – 3:00 PM Eastern Time

Stratification of Systemic Lupus Erythematosus (SLE) Patients Based on the Molecular Patterns of Mouse Models
Abstract Poster Presenter: María Rivas Torrubia, MSc – GENYO. Centre for Genomics and Oncological Research
1:00 PM – 3:00 PM Eastern Time

MHC Class I Polypeptide-Related Sequence a Variant Predicts Real-World Response to Anti-TNF Therapy
Abstract Poster Presenter: Kristin Wipfler, PhD – FORWARD, The National Databank for Rheumatic Diseases
1:00 PM – 3:00 PM Eastern Time

WITHDRAWN
1:00 PM – 3:00 PM Eastern Time

Molecular Pathways Identified from Risk Alleles Identify Mechanistic Differences in Systemic Lupus Erythematosus Patients of East Asian and European Ancestry
Abstract Poster Presenter: Katherine Owen, PhD – RILITE
1:00 PM – 3:00 PM Eastern Time

WITHDRAWN
1:00 PM – 3:00 PM Eastern Time

Consequences of SLE Heterogeneity on the Epigenome and the Drivers Behind
Abstract Poster Presenter: Olivia Castellini Pérez, MSc – University of Granada
1:00 PM – 3:00 PM Eastern Time

The Lupus Risk Allele Associated Xq28 Haplotype Identifies the Molecular Endotype of a Cohort of European SLE Patients with Enhanced IRAK1 Signaling
Abstract Poster Presenter: Katherine Owen, PhD – RILITE
1:00 PM – 3:00 PM Eastern Time

Epigenome-wide Analysis of Osteoarthritis in the Multicenter Osteoarthritis Study
Abstract Poster Presenter: Michelle Yau, PhD, MPH – Hebrew SeniorLife
1:00 PM – 3:00 PM Eastern Time

Circulating miRNAs and Difficult-To-Treat Rheumatoid Arthritis: The Screening Study
Abstract Poster Presenter: Jiri Baloun, PhD – Institute of Rheumatology
1:00 PM – 3:00 PM Eastern Time

The Prostate Plays a Role in Serum Urate Levels and the Risk of Gout in Men
Abstract Poster Presenter: Mariana Urquiaga, MD – University of Alabama at Birmingham
1:00 PM – 3:00 PM Eastern Time

Genetic Interactions Between T-Cell Receptor Polymorphisms and HLA Amino Acids Contribute to the Risk of Rheumatoid Arthritis
Abstract Poster Presenter: Sebastien Viatte, MD, PhD – The University of Manchester
1:00 PM – 3:00 PM Eastern Time

Transcriptomic Changes Induced by Tocilizumab in Ex-Vivo PBMCs from Patients with GCA in Remission. Predictors of Response
Abstract Poster Presenter: FARAH KAMBEROVIC, MSc – Faculty of Medicine, University of Barcelona
1:00 PM – 3:00 PM Eastern Time

GWAS Identified New Genes in Synovial Fibroblasts Linked to Early Remission in RA
Abstract Poster Presenter: Marc Maurits, MSc – LUMC
1:00 PM – 3:00 PM Eastern Time

A Novel Mitochondrial Variant as a Predictor for the Rapid Progressive Knee Osteoarthritis Phenotype: Development of a Predictive Model and Functional Studies
Abstract Poster Presenter: Alejandro Durán-Sotuela, BSc, MSc – Fundacion Profesor Novoa Santos