(1166–1185) Systemic Sclerosis and Related Disorders – Basic Science Poster

Poster abstract session.

Presentations:

• 1:00 PM – 3:00 PM Eastern Time

  Scleroderma Fibroblasts Induce Alternative Macrophage Activation via an ERK1/2-dependent Mechanism
  

  Abstract Poster Presenter: Andreea M. Bujor, MD – Boston University
• 1:00 PM – 3:00 PM Eastern Time

  Towards an Autologous 3D Skin-like Tissue Harboring Patient-Derived Fibroblasts, Keratinocytes, T-cells and Macrophages
  

  Abstract Poster Presenter: Sasha Shenk, BS – Tufts University
• 1:00 PM – 3:00 PM Eastern Time

  Dermal Fibroblast-derived Exosomes Drive Profibrotic Macrophage Activation in Systemic Sclerosis
  

  Abstract Poster Presenter: Heetaek Yang, BS – Dartmouth College
• 1:00 PM – 3:00 PM Eastern Time

  Downregulated Fli1 in Systemic Sclerosis Myeloid Cells Contributes to Enhanced Transendothelial Migration
  

  Abstract Poster Presenter: Pablo Weilg Espejo, MD – Boston Medical Center
• 1:00 PM – 3:00 PM Eastern Time

  Systemic Sclerosis Dermal Fibroblast-derived Exosomes Trigger a Type 1 Interferon Rresponse in Keratinocytes Through TBK1
  

  Abstract Poster Presenter: Jessica Bryon, MSc – University of Leeds
• 1:00 PM – 3:00 PM Eastern Time

  Distinct Immune Cell Subsets in Systemic Sclerosis-related Interstitial Lung Disease
  

  Abstract Poster Presenter: Phan Saligrama, MD, PhD – Washington University
• 1:00 PM – 3:00 PM Eastern Time

  Transcription Analysis of Macrophages Reveals Important Changes Induced by Systemic Sclerosis Fibroblasts
  

  Abstract Poster Presenter: Juan-Pablo Zertuche, MD – Boston University
• 1:00 PM – 3:00 PM Eastern Time

  Single-cell Multi-omic Analysis of a 3D Skin-Like Tissue Model Provides Insights into Molecular and Cellular Drivers of Systemic Sclerosis
  

  Abstract Poster Presenter: Tamar R. Abel, BS – Dartmouth College
• 1:00 PM – 3:00 PM Eastern Time

  Cellular Immunotherapy for Systemic Sclerosis
  

  Abstract Poster Presenter: Chanhyuk Park, BA – Geisel School of Medicine at Dartmouth
• 1:00 PM – 3:00 PM Eastern Time

  Epigenetic Regulation of MicroRNA-126 in Scleroderma Is Associated with Upregulation of DNA Methyltransferase-1, Repression of Endothelial Nitric Oxide Synthase Expression, and Enhanced Platelet Adhesion to Endothelial Cells
  

  Abstract Poster Presenter: Yongqing Wang, PhD – University of Toledo Medical Center
• 1:00 PM – 3:00 PM Eastern Time

  Immunoglobulins G from Systemic Sclerosis Patients May Alter the Secretome of Dermal Fibroblasts
  

  Abstract Poster Presenter: Aurélien Chepy, MD – INFINTE U186 inserm, univeristy of Lille
• 1:00 PM – 3:00 PM Eastern Time

  Identification of a New Type of Pro-phagocytic Macrophages in Patients with Systemic Sclerosis
  

  Abstract Poster Presenter: Amela Hukara, MSc – University Hospital Zurich, University of Zurich
• 1:00 PM – 3:00 PM Eastern Time

  Key Features of Human Fibrosing Interstitial Lung Disease Are Captured in a Preclinical Mouse Model upon Repetitive, but Not Single Intratracheal Bleomycin Dosing
  

  Abstract Poster Presenter: David Lauer, MSc – University Hospital Bern
• 1:00 PM – 3:00 PM Eastern Time

  Single Cell RNA Sequencing Analysis of Cryopreserved versus Fresh Skin Biopsy Samples from Systemic Sclerosis Patients and Healthy Controls
  

  Abstract Poster Presenter: Brian Skaug, MD, PhD – University of Texas McGovern Medical School at Houston
• 1:00 PM – 3:00 PM Eastern Time

  Deficiency and Altered Phenotype of Mucosal-associated Invariant T Cells in Systemic Sclerosis
  

  Abstract Poster Presenter: Manon LESTURGIE-TALAREK, MD – Paris University
• 1:00 PM – 3:00 PM Eastern Time

  Hippo Pathway Effectors Promote and Maintain Myofibroblast Differentiation and Endothelial-to-mesenchymal Transition in Systemic Sclerosis
  

  Abstract Poster Presenter: Feiyang Ma, PhD – University of Michigan, Ann Arbor
• 1:00 PM – 3:00 PM Eastern Time

  Evaluation of Efficacy, Immunogenicity, and Toxicity of a Novel Drug Candidate for Scleroderma-associated Interstitial Lung Disease
  

  Abstract Poster Presenter: Galina Bogatkevich, MD, PhD – Medical University of South Carolina
• 1:00 PM – 3:00 PM Eastern Time

  Functionally Distinct Fibroblast Populations in Systemic Sclerosis Skin Revealed by Explant Tissue Characterization and Single-cell RNAseq
  

  Abstract Poster Presenter: Kristina Clark, MD, MRCP – University College London
• 1:00 PM – 3:00 PM Eastern Time

  Intracellular Calcium Signals Regulate the Pro-fibrotic Phenotype of Scleroderma Fibroblasts via Calcium/calmodulin-dependent Kinase II
  

  Abstract Poster Presenter: Eliza Pei-Suen Tsou, PhD – University of Michigan
• 1:00 PM – 3:00 PM Eastern Time

  Interleukin-11 Promotes Fibrosis Through Classic and Trans-signaling Pathway in Systemic Sclerosis
  

  Abstract Poster Presenter: Wenjing Ye, PhD – Department of Rheumatology, Huashan Hospital, Fudan University