(1681–1706) Innate Immunity Poster: Basic and Translational Science

Monday, November 14, 2022

1:00 PM – 3:00 PM Eastern Time

Location: Virtual Poster Hall

All of the relevant financial relationships listed for faculty have been mitigated.

Poster abstract session.

Presentations:

1:00 PM – 3:00 PM Eastern Time

Supernatants from Activated Macrophages Contain Citrullinated Vimentin and Induce Extracellular Matrix Deposition from Fibroblasts
Abstract Poster Presenter: Nozima Aripova, BS – University of Nebraska Medical Center
1:00 PM – 3:00 PM Eastern Time

Peptidyl Arginine Deiminase Expression and Macrophage Polarization Following Stimulation with Citrullinated and Malondialdehyde-acetaldehyde Modified Fibrinogen
Abstract Poster Presenter: Nozima Aripova, BS – University of Nebraska Medical Center
1:00 PM – 3:00 PM Eastern Time

Malondialdehyde-Acetaldehyde (MAA) Modified Matrix Gla Protein (MGP) Increases Citrullination by Human Macrophages
Abstract Poster Presenter: Spencer Jones, BS – University of Nebraska College of Medicine
1:00 PM – 3:00 PM Eastern Time

A Potent Inhibitor of PAD4 Suppresses Histone Citrullination in Vitro and in Vivo
Abstract Poster Presenter: Gundula Min-oo, PhD – Gilead Sciences
1:00 PM – 3:00 PM Eastern Time

The Presence of Anti-MAA Antibodies to Extracellular Matrix Proteins in Synovial Fluid and Sera of Patients with Rheumatoid Arthritis
Abstract Poster Presenter: Alexandra Taylor, BS – Creighton University School of Medicine
1:00 PM – 3:00 PM Eastern Time

Post-translational Modification of Matrix-gla Protein with Malondialdehyde-Acetaldehyde Alters Cellular Responses by Human Fibroblasts
Abstract Poster Presenter: Austin Ragland, BS – University of Nebraska Medical Center
1:00 PM – 3:00 PM Eastern Time

A Core Inflammation Program Conserved Across Human and Murine Neutrophils
Abstract Poster Presenter: Nicolaj Hackert, -None- – Heidelberg University (Germany)/Harvard Medical School
1:00 PM – 3:00 PM Eastern Time

Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis
Abstract Poster Presenter: Noelle Pisacano, BSc, MSc – Imperial College London
1:00 PM – 3:00 PM Eastern Time

Oral Ginger Supplementation Counteracts NETosis in Autoimmune Mouse Models and in Healthy Humans
Abstract Poster Presenter: Ramadan Ali, PhD – University of Michigan
1:00 PM – 3:00 PM Eastern Time

Butyric Acid Suppresses Migration of Human Monocyte Derived Dendritc Cell by Inhibiting Actin Polymerization via mDia1 Inhibition
Abstract Poster Presenter: Takumi Nagamoto, MD – Kobe University
1:00 PM – 3:00 PM Eastern Time

Pentagalloyl Glucose Inhibits MSU-Induced Inflammation via Transforming Growth Factor-β-Activated Kinase 1 (TAK1)
Abstract Poster Presenter: Paul Panipinto, BS – Washington State University College of Pharmaceutical Science and Molecular Medicine
1:00 PM – 3:00 PM Eastern Time

Interferon Alpha Promotes Ultraviolet Light-Mediated Keratinocyte Apoptosis in a Caspase-8 Dependent Manner via Upregulation of Interferon Regulatory Factor 1
Abstract Poster Presenter: Shannon Estadt, BS – University of Michigan
1:00 PM – 3:00 PM Eastern Time

Skin Pigmentation Association with Regulation of Cyclic-GMP-AMP Following Skin Exposure to UV Light
Abstract Poster Presenter: Jie An, PhD – University of Washington
1:00 PM – 3:00 PM Eastern Time

Skin Exposure to UV Light Triggers Podocyte and Distal Tubular Injury, in the Presence of CD177+ Neutrophil Cell Cluster
Abstract Poster Presenter: Angelique Cortez, BS – Dartmouth Hitchcock Medical Center
1:00 PM – 3:00 PM Eastern Time

Dermatomyositis (DM) Macrophages Upregulate Genes Involved in the Remodeling of the Extracellular Matrix and Activate Keratinocytes in a Novel 3D Tissue Model of DM Skin Disease
Abstract Poster Presenter: Zoe Chafouleas – Dartmouth College
1:00 PM – 3:00 PM Eastern Time

Single Cell RNA-seq Identifies Major Shifts in Myeloid Cells in Dermatomyositis Skin and Peripheral Blood Compared to Systemic Lupus
Abstract Poster Presenter: Grace Hile, MD – University of Michigan
1:00 PM – 3:00 PM Eastern Time

Measurements of Specific Activation Through the Lectin -or Classical Pathway of Complement in Patients with SLE
Abstract Poster Presenter: Anne Troldborg, MD, PhD – Aarhus University Hospital
1:00 PM – 3:00 PM Eastern Time

LINE1 Reverse Transcriptase Inhibitors Abrogate Type 1 Interferon Responses
Abstract Poster Presenter: Daniel Rios, PhD – Rome Therapeutics
1:00 PM – 3:00 PM Eastern Time

Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations
Abstract Poster Presenter: Yidan Wang – Northwestern University
1:00 PM – 3:00 PM Eastern Time

WITHDRAWN
1:00 PM – 3:00 PM Eastern Time

High TNFAIP3-Transfected Cell Activity: An In Vitro Model for Phagocyte Study of Monogenic Behçet’s Disease Pathophysiology
Abstract Poster Presenter: Patricia Pontes Aires, MD – Universidade Federal de Sao Paulo
1:00 PM – 3:00 PM Eastern Time

Targeting CD6-CD318 Axis with UMCD6 (anti-CD6) Enhances in Vivo Killing of Cancer Cells Through Direct Activation of NK Cells
Abstract Poster Presenter: Mikel Gurrea-Rubio, PhD – University of Michigan - Ann Arbor
1:00 PM – 3:00 PM Eastern Time

Potential Regulation of NK Cells by CD1c+ Dendritic Cells Through RIG-I/DDX60 Pathway Involved in Th17 Responses in Primary Sjögren Syndrome
Abstract Poster Presenter: Ildefonso Sánchez, MD – Hospital Universitario La Princesa
1:00 PM – 3:00 PM Eastern Time

Interaction of Macrophages and Natural Killer Cells in Pathogenesis of HIV-1-Associated Inflammatory Arthritis
Abstract Poster Presenter: Can Sungur, MD, PhD – Washington University
1:00 PM – 3:00 PM Eastern Time

Peptidoglycan Amplifies CD4+ T Cell Activation by MHCII+ Fibroblast-like Synoviocytes in an in Vitro Model of Lyme Arthritis
Abstract Poster Presenter: Robert Lochhead, PhD – Medical College of Wisconsin
1:00 PM – 3:00 PM Eastern Time

Clinical and Immunological Factors Associated with Chronic Post-COVID19 Syndrome 12 Months After Acute Infection
Abstract Poster Presenter: Emmanuel Camacho, MD – INCMNSZ