(0589–0628) RA – Etiology and Pathogenesis Poster

Sunday, November 13, 2022

9:00 AM – 10:30 AM Eastern Time

Location: Virtual Poster Hall

All of the relevant financial relationships listed for faculty have been mitigated.

Poster abstract session.

Presentations:

9:00 AM – 10:30 AM Eastern Time

Restoration of NAD⁺ Levels in Rheumatoid Arthritis with NAD⁺ Boosters as a Novel Therapeutic Strategy to Resolve Acute Inflammation
Abstract Poster Presenter: Carlos Perez-Sanchez, PhD – IMIBIC
9:00 AM – 10:30 AM Eastern Time

Molecular Profiling of Normal Human Synovium Reveals Striking Impact of Adipocytes and Homeostatic Cortisol Signaling
Abstract Poster Presenter: Heather Faust, PhD – Brigham and Women's hospital
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Autoantibodies Targeting Malondialdehyde-modifications Are Potential Mediators of Inflammation and Bone Loss in RA, Acting via Macrophage and Osteoclast Regulatory Pathways
Abstract Poster Presenter: Bence Réthi, PhD – Karolinska Institutet
9:00 AM – 10:30 AM Eastern Time

A New Cytokine Interleukin 40 Is Elevated in the Serum of Patients with Early Rheumatoid Arthritis and Associates with Autoantibodies and Neutrophil Activation
Abstract Poster Presenter: Adela Navratilova, MSc – Institute of Rheumatology
9:00 AM – 10:30 AM Eastern Time

Identification of Peptidylglycine Alpha-Amidating Monooxygenase as a Regulator of Tissue Damage Mediated by Rheumatoid Arthritis Synovial Fibroblasts
Abstract Poster Presenter: Kevin Sheridan, PhD, BSc – University College Dublin
9:00 AM – 10:30 AM Eastern Time

Validation of Urotensin-2 mRNA Expression as Marker for Tocilizumab Non-Response in Early Rheumatoid Arthritis
Abstract Poster Presenter: Janani Sundaresan, MSc – Amsterdam UMC - VuMC
9:00 AM – 10:30 AM Eastern Time

Neutrophil Extracellular Traps (NET) Trigger an Enhanced Pro-inflammatory Response in Macrophage Subpopulations in Rheumatoid Arthritis Patients via the Aryl Hydrocarbon Receptor (AhR) Pathway
Abstract Poster Presenter: Patrice Decker, PhD, Prof. – University Sorbonne Paris Nord
9:00 AM – 10:30 AM Eastern Time

TNF-α Utilizes the TWEAK/Fn-14 Axis in Human Rheumatoid Arthritis Synovial Fibroblasts
Abstract Poster Presenter: Farheen Sultan Shaikh, MSc – Washington State University
9:00 AM – 10:30 AM Eastern Time

An Arthritogenic Strain of Subdoligranulum Specifically Detectable in the Feces of Individuals At-risk for and with Rheumatoid Arthritis Is Bound by ACPA and Stimulates Th17 Cell Activation in Those with Rheumatoid Arthritis
Abstract Poster Presenter: Meagan Chriswell, MD, PhD – UC Denver SOM
9:00 AM – 10:30 AM Eastern Time

Expansion of HLA-DR+CD45RAhi Non-lymphoid Cells in Patients with Rheumatoid Arthritis
Abstract Poster Presenter: Christian Geier, MD – SUNY Upstate Medical University
9:00 AM – 10:30 AM Eastern Time

Correlates Between Rheumatoid Arthritis Clinical Factors and Synovial Cell Phenotypes: Data from the Accelerated Medicines Partnership
Abstract Poster Presenter: Katherine Liao, MD, MPH – Brigham and Women's Hospital
9:00 AM – 10:30 AM Eastern Time

Occupational Inhaled Agents Constitute Major Risk Factors for Rheumatoid Arthritis, Particularly in the Context of Genetic Predisposition and Smoking
Abstract Poster Presenter: Qianwen Liu, MBBS, MMSc – Karolinska Instututet
9:00 AM – 10:30 AM Eastern Time

Cellworks Biosimulation Model (CBM) for Rheumatoid Arthritis (RA), Accurately Captures Patient’s Disease Activity at the Molecular Level Using Their Omics Data and Can Bring Personalization to Treatment Selection in RA
Abstract Poster Presenter: Himanshu Grover, MSc – Cellworks Group, Inc.
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Altered Metabolic State in Myeloid Precursors and Mature Cells Within Rheumatoid Arthritis
Abstract Poster Presenter: Patricia Riedlova, MSc – University of Glasgow -School of Infection and Immunity
9:00 AM – 10:30 AM Eastern Time

Citrullinated Peptide-Specific ACPA Are Present in the Female Genital Tract in Premenopausal Women with and Without RA
Abstract Poster Presenter: Daniele Marcy, MD, BS – University of Colorado
9:00 AM – 10:30 AM Eastern Time

Mechanism of Joint-Specific Homeobox D10 Regulation in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Abstract Poster Presenter: Hyeonjeong Lee, PhD – University of California San Diego
9:00 AM – 10:30 AM Eastern Time

Cadherin 6 Regulates Rheumatoid Arthritis Fibroblasts-Like Synoviocyte Aggressiveness
Abstract Poster Presenter: Camilla Machado, PhD – UCSD
9:00 AM – 10:30 AM Eastern Time

Wnt Pathway Regulators R-spondin 3 and Dickkopf-related Protein 3 Demarcate a Transcriptional Gradient That Drives Synovial Fibroblast Inflammatory Pathology in Rheumatoid Arthritis
Abstract Poster Presenter: Alisa Mueller, MD, PhD – Brigham and Women's Hospital
9:00 AM – 10:30 AM Eastern Time

Macrophage Response to MAA Modified Fibrinogen in the Presence of Peptidyl Arginine Deiminase Inhibitor
Abstract Poster Presenter: Nozima Aripova, BS – University of Nebraska Medical Center
9:00 AM – 10:30 AM Eastern Time

Patient-derived Organoids Reveal Transcriptional Regulation of Synovial Lining Fibroblast Differentiation
Abstract Poster Presenter: Sonia Presti, BS – Brigham and Women's Hospital
9:00 AM – 10:30 AM Eastern Time

Proteomics Reveals Dysregulated Molecular Mechanisms of Cell Death in Neutrophils in Rheumatoid Arthritis
Abstract Poster Presenter: Jennifer Amsler, MD – Institut Cochin
9:00 AM – 10:30 AM Eastern Time

Peripheral Blood and Synovial Fluid Natural Killer (NK) and Natural Killer T (NKT) Cell Immunophenotypes in Active Rheumatoid Arthritis and Their Role as Biomarkers of Methotrexate Response
Abstract Poster Presenter: Siddharth Jain, MD, MBBS, DM, MRCP – Postgraduate Institute of Medical Education and Research, Chandigarh, India
9:00 AM – 10:30 AM Eastern Time

The Subsets of Synovial Fluid Derived Fibroblasts in Clinical Features of Rheumatoid Arthritis
Abstract Poster Presenter: Kuninobu Wakabayashi, MD, PhD – Division of Rheumatology, Department of Medicine, Showa University School of Medicine
9:00 AM – 10:30 AM Eastern Time

Post-translationally Modified Fibrinogen Activated Macrophages Drive the Expression of Fibrotic Genes in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Abstract Poster Presenter: Nozima Aripova, BS – University of Nebraska Medical Center
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Serum Proteomic Networks Associate with Pre-clinical Rheumatoid Arthritis Autoantibodies and Longitudinal Outcomes
Abstract Poster Presenter: Liam O'Neil, MD, MHS – University of Manitoba
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Regulation of IgA Secretion Through PAD2-mediated Citrullination of MZB1
Abstract Poster Presenter: Benjamin Geary, BA – Brigham and Women's Hopsital
9:00 AM – 10:30 AM Eastern Time

Differences Between Patients in Remission with Active Rheumatoid Arthritis by Histological and Molecular Comparisons
Abstract Poster Presenter: Selina Ohl, BSc, MSc – Justus-Liebig-University Gießen
9:00 AM – 10:30 AM Eastern Time

Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo
Abstract Poster Presenter: Corinna Heck, BSc, MSc – Justus-Liebig-University
9:00 AM – 10:30 AM Eastern Time

Altered Immunological Circadian Rhythms and the Effect of Treatment with Glucocorticoids on Circadian Rhythms of Immune Cells in Patients with Rheumatoid Arthritis: Bring Back the Rhythm
Abstract Poster Presenter: Siska Wilantri, MSc – Charité Universitätsmedizin Berlin
9:00 AM – 10:30 AM Eastern Time

Commensal Reactive T-cells Display Diverse Phenotype in Rheumatoid Arthritis Patients
Abstract Poster Presenter: Sumbul Afroz, PhD – Perelman School of Medicine, UPenn
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

CD20+ T Cells in the Synovial Fluid of Patients with Rheumatoid Arthritis Suggest a Role for Trogocytosis in Disease Pathogenesis and Activity
Abstract Poster Presenter: Maria De Santis, MD, PhD – Humanitas University
9:00 AM – 10:30 AM Eastern Time

Distinct Effects of JAK Inhibitor and TNF Inhibitors on Circulating B Cell Phenotypes in Rheumatoid Arthritis Patients
Abstract Poster Presenter: Mehreen Elahee, MD – University of Pittsburgh Medical Center
9:00 AM – 10:30 AM Eastern Time

Elucidating the Expression and Role of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) in Human Rheumatoid Arthritis Synovial Fibroblasts and a Rat Adjuvant-induced Arthritis Model
Abstract Poster Presenter: Meena Afroze Shanta, MS – College of Pharmacy and Pharmaceutical Science, Washington State University
9:00 AM – 10:30 AM Eastern Time

Spatial Transcriptomic Analysis Reveals Vascular Zonation of Myofibroblasts in Rheumatoid Arthritis Synovium
Abstract Poster Presenter: Kartik Bhamidipati, PhD – Brigham and Women's Hospital
9:00 AM – 10:30 AM Eastern Time

A Positive-feedback Model for the Contribution of Virus-Specific T Cells to the Development of Rheumatoid Arthritis
Abstract Poster Presenter: Hendrik Nel, PhD – University of Queensland, Brisbane, Australia