(0629–0670) SLE – Etiology and Pathogenesis Poster

Sunday, November 13, 2022

9:00 AM – 10:30 AM Eastern Time

Location: Virtual Poster Hall

All of the relevant financial relationships listed for faculty have been mitigated.

Poster abstract session.

Presentations:

9:00 AM – 10:30 AM Eastern Time

The Cellular Metabolism of SLE NK Cells Is Primarily Altered at the Level of Mitochondrial Respiration
Abstract Poster Presenter: Natalia Fluder, MSc – University Hospital and University of Lausanne
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Perfluoroalkyl Substances and Community Vulnerability: Associations with Lupus-Related Autoantibodies and Disease
Abstract Poster Presenter: Emily Vara, DO – Medical University of South Carolina
9:00 AM – 10:30 AM Eastern Time

Single-cell Multiomic Profiling Differentiates Ancestral B Cell Pathologies Contributing to Lupus Disease Activity
Abstract Poster Presenter: Kevin Thomas, BSc – Oklahoma Medical Research Foundation
9:00 AM – 10:30 AM Eastern Time

Identification of Systemic Lupus Erythematosus Endotypes by Analysis of Inflammatory and Immunologic Gene Expression Signatures
Abstract Poster Presenter: Erika Hubbard, BSc – AMPEL BioSolutions
9:00 AM – 10:30 AM Eastern Time

Total Interstitial Inflammation Predicts Chronic Kidney Disease Progression in Patients with Lupus Nephritis
Abstract Poster Presenter: Shudan Wang, MD, MS – Albert Einstein College of Medicine
9:00 AM – 10:30 AM Eastern Time

Blood RNA-sequencing Reveals Complex Immune Dysregulation in ANA-positive Individuals with Distinct Profiles Preceding Progression to SLE versus Stable Autoimmunity
Abstract Poster Presenter: Lucy Carter, PhD, BSc, MRCP – University of Leeds
9:00 AM – 10:30 AM Eastern Time

Serum Soluble Mediator Signatures of Lupus Nephritis Histological Features and Response to Treatment
Abstract Poster Presenter: Andrea Fava, MD – Johns Hopkins University
9:00 AM – 10:30 AM Eastern Time

Reduced IgG Sialic Acid Content: A Distinctive Characteristic of Symptomatic Anti-Nuclear Antibodies Positive Individuals
Abstract Poster Presenter: Carolina Munoz-Grajales, MD – UHN/TWH
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

Association of Gut Microbiome Streptococcus, Health Status, Cytokines, and HLA Class in Anti-Ro+ Mothers of Children with Neonatal Lupus: Insights into Progression of Clinical Autoimmunity
Abstract Poster Presenter: Robert Clancy, PhD – NYU Grossman School of Medicine
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

IL-4 Receptor Signaling and IKAROS Transcriptomic Program Maintains Naïve B-cell Quiescence and Antagonizes SLE
Abstract Poster Presenter: John D. Mountz, MD, PhD – University Alabama Birmingham
9:00 AM – 10:30 AM Eastern Time

SLAMF6-SAP Signaling Unit Is Increased in SLE T Follicular Helper Cells
Abstract Poster Presenter: Yevgeniya Gartshteyn, MD, MS – Columbia University Medical Center
9:00 AM – 10:30 AM Eastern Time

Subsetting SLE Patients Based on DNA Methylation at the Time of Disease Flare
Abstract Poster Presenter: Mary Horton, PhD, MPH – National Institutes of Health
9:00 AM – 10:30 AM Eastern Time

Long-lived Plasma Cells in the Lupus Bone Marrow Are Imprinted by Interferon
Abstract Poster Presenter: Jennifer Barnas, MD, PhD, BS – University of Rochester
9:00 AM – 10:30 AM Eastern Time

Lupus Fibroblasts from Non-lesional Skin Exhibit Exaggerated Responses to Inflammatory Cytokines and Upregulate Pro-fibrotic Collagens in Patients with Scarring Lesions
Abstract Poster Presenter: Suzanne Shoffner-Beck, BS – University of Michigan
9:00 AM – 10:30 AM Eastern Time

Modulation of Type I IFN Production and Regulatory T Cells by the PKGI/ROCK Signaling Pathway
Abstract Poster Presenter: Ruth Fernandez Ruiz, MD, MSc – Hospital for Special Surgery / Weill Cornell Medicine
9:00 AM – 10:30 AM Eastern Time

Transcriptomic Analysis of Lupus Nephritis Kidneys Identifies Molecular Endotypes
Abstract Poster Presenter: Kathryn Kingsmore Allison, PhD – AMPEL BioSolutions
9:00 AM – 10:30 AM Eastern Time

Pathogenic Anti-C1q Antibodies Potentiate Activation of the Classical Complement Pathway in a Subset of Lupus Nephritis Patients
Abstract Poster Presenter: Edmund Chang, PhD – Annexon Biosciences
9:00 AM – 10:30 AM Eastern Time

Phosphofructokinase P Fine-Tunes T Regulatory Cell Metabolism, Function and Stability in Systemic Autoimmunity
Abstract Poster Presenter: Marc Scherlinger, MD, PhD – Beth Israel Deaconess Medical Center Harvard University
9:00 AM – 10:30 AM Eastern Time

The Association of Urinary C9 to CD59 Ratio with Tubulointerstitial Fibrosis in Lupus Nephritis
Abstract Poster Presenter: Shudan Wang, MD, MS – Albert Einstein College of Medicine
9:00 AM – 10:30 AM Eastern Time

Inflammatory Dendritic Cell Drive Intra-renal T Cells to Double-negative T Cell in Lupus Nephritis
Abstract Poster Presenter: Latha Prabha Ganesan, PhD – The Ohio State University
9:00 AM – 10:30 AM Eastern Time

Serum from Patients with SLE and Anti-MDA5 Antibody-Positive Dermatomyositis Induce Shared Monocyte Cytokine Signature Through Type 1 Interferon Pathway
Abstract Poster Presenter: Shohei Nakamura, MD – Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine
9:00 AM – 10:30 AM Eastern Time

JAK Inhibitors Counteract Cellular Toxicity of Hydroxychloroquine in Vitro
Abstract Poster Presenter: Hiroshi Kajiyama, MD, PhD – Saitama Medical University
9:00 AM – 10:30 AM Eastern Time

Lymphatic Dysfunction and Immune Activation in Lupus
Abstract Poster Presenter: William Ambler, MD – NIH/NIAMS
9:00 AM – 10:30 AM Eastern Time

Proteomic Analysis of Histological Lesions Lupus Nephritis Identifies an Inflammatory Signature of Fibrous Crescents
Abstract Poster Presenter: Alessandra Ida Celia, MD – Johns Hopkins University
9:00 AM – 10:30 AM Eastern Time

WITHDRAWN
9:00 AM – 10:30 AM Eastern Time

DB-2304, a Novel anti-BDCA2 Monoclonal Antibody Drug Conjugate, Displayed Great Potency in Suppression of pDC Functions
Abstract Poster Presenter: Xi Li, PhD – Duailty Biologics
9:00 AM – 10:30 AM Eastern Time

Integrative Analysis of Cell-Specific Human Endogenous Retrovirus Expression and Host Gene Expression Identifies Associations with Clinical SLE Phenotypes
Abstract Poster Presenter: Zach Cutts, -None- – UCSF
9:00 AM – 10:30 AM Eastern Time

Comprehensive Proteomic Screen of Murine Lupus Serum and Cerebrospinal Fluid Uncovers Diagnostic and Therapeutic Targets
Abstract Poster Presenter: Joshua Reynolds, MS, BS – Albert Einstein COM
9:00 AM – 10:30 AM Eastern Time

Serum Proteins and Metabolites Differ in SLE Patients with Coronary Microvascular Dysfunction (CMD) as Determined by Cardiac MRI Compared to SLE Patients Without CMD – a Pilot Study
Abstract Poster Presenter: Audrey Hagiwara, MD – Cedars-Sinai Medical Center
9:00 AM – 10:30 AM Eastern Time

Cutaneous Type I IFN Responses in Systemic Lupus Erythematosus Are Associated with Inflammatory Phenotype and Altered Wound Healing Function of Lupus Fibroblasts from Non-Lesional Skin
Abstract Poster Presenter: Lisa Abernathy-Close, PhD – University of Michigan
9:00 AM – 10:30 AM Eastern Time

Partial Correlations Network Models Show Th1, Th2 and Th17 Responses to Be Interlinked in Dermal Pathogenesis of Cutaneous Lupus Erythematous
Abstract Poster Presenter: Felix Chin, BS – University of Pennsylvania Perelman School of Medicine
9:00 AM – 10:30 AM Eastern Time

Anti-Erythrocyte Antibodies in Childhood Onset Systemic Lupus Erythematosus
Abstract Poster Presenter: Lauren Robinson, MD – Hospital for Special Surgery
9:00 AM – 10:30 AM Eastern Time

Development of a Novel Gene Expression-based Molecular Score That Characterizes Individual Lupus Patients
Abstract Poster Presenter: Prathyusha Bachali, MS – AMPEL BioSolutions
9:00 AM – 10:30 AM Eastern Time

Screening for Neurocognitive Demands in Childhood-onset Systemic Lupus Erythematosus Patients Using Pediatric Automated Neuropsychological Assessment Metrics and Association with Magnetic Resonance Imaging
Abstract Poster Presenter: Jaqueline de Amorim, BSc – University of Campinas
9:00 AM – 10:30 AM Eastern Time

HRES-1/Rab4 Controls the Overexpression of CD38 and Depletion of IL-2 in CD4⁺ T Cells; Potential Involvement in Proinflammatory Lineage Development in SLE
Abstract Poster Presenter: Seong Hee (Joy) Park, BA – Upstate Medical University
9:00 AM – 10:30 AM Eastern Time

Correlation Matrices Visualize Differential Degree of Cell and Pathway Heterogeneity in Skin of Cutaneous Lupus Erythematosus Treatment Subgroups
Abstract Poster Presenter: Felix Chin, BS – University of Pennsylvania Perelman School of Medicine
9:00 AM – 10:30 AM Eastern Time

Differential Expression of Interferon Related Genes in SLE Patients of Asian and European Ancestries Abstract
Abstract Poster Presenter: Ian Rector, BA – AMPEL Biosolutions
9:00 AM – 10:30 AM Eastern Time

Understanding How Type I Interferon Modulates Langerhans Cell ADAM17 to Promote Photosensitivity in Lupus
Abstract Poster Presenter: Thomas Li, BA – Hospital for Special Surgery
9:00 AM – 10:30 AM Eastern Time

A Short Allelic Epitope Coded by HLA-DRB1*03:01 Activates a Systemic Lupus Erythematosus Cell Aberration Cascade
Abstract Poster Presenter: Bruna Miglioranza Scavuzzi, PhD – University of Michigan