13S170: Abstracts: Systemic Sclerosis and Related Disorders – Basic Science (1621–1624)

Abstract Moderator(s)

• OD

  Oliver Distler, MD

  Department of Rheumatology, University Hospital Zurich, University of Zurich, Switzerland
  Zurich, Switzerland

  Disclosure(s): 4P-Pharma: Consultant (Ongoing); Abbvie: Consultant (Ongoing); Alcimed: Employee (Terminated); Altavant Siences: Consultant (Ongoing); AnaMar: Consultant (Ongoing); Arxx: Consultant (Ongoing); AstraZeneca: Consultant (Terminated); Bayer: Consultant (Terminated); Blade: Consultant (Ongoing); Boehringer Ingelheim: Advisor or Review Panel Member (Ongoing), Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Corbus: Consultant (Ongoing); CSL Behring: Consultant (Ongoing); Galapagos: Consultant (Terminated); Glenmark: Consultant (Ongoing); Gossamer: Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Kymera: Consultant (Ongoing), Research Grant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Lupin: Consultant (Terminated), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Terminated); Medscape: Consultant (Terminated), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Terminated); Miltenyi Biotec: Consultant (Ongoing); Mitsubishi Tanabe: Consultant (Ongoing), Research Grant (Ongoing); MSD Merck: Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Novartis: Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Terminated); Prometheus: Consultant (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Redxpharna: Consultant (Ongoing); Roivant: Consultant (Terminated); Topadur: Consultant (Ongoing)
• 

  Benjamin Korman, MD

  University of Rochester
  Rochester, NY, United States

  Disclosure(s): No financial relationships to disclose

Oral abstract session.

Presentations:

• 5:00 PM – 5:10 PM Eastern Time

  Genome-wide Association Study in African American Systemic Sclerosis Patients Identifies a Novel Target - Transforming Growth Factor-β3 (TGFβ3)
  

  Presenting Author: Urvashi Kaundal, PhD – National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH)
• 5:10 PM – 5:15 PM Eastern Time

  Q&A
  
• 5:15 PM – 5:25 PM Eastern Time

  TNF Receptor 1 Drives Murine Pulmonary Arterial Hypertension and Is Characterized by Loss of Capillary Endothelial Cells and Pericytes, Smooth Muscle Cell Proliferation, and Alterations in Fibroblast Phenotype
  

  Presenting Author: Benjamin D. Korman, MD – University of Rochester
• 5:25 PM – 5:30 PM Eastern Time

  Q&A
  
• 5:30 PM – 5:40 PM Eastern Time

  Combined Single-Cell, Bulk RNA Sequencing and Proteomics Analysis Reveals New Candidate Targets Involved in Myocardial Fibrogenesis
  

  Presenting Author: Ievgeniia Kocherova, MSc – University of Zurich
• 5:40 PM – 5:45 PM Eastern Time

  Q&A
  
• 5:45 PM – 5:55 PM Eastern Time

  Blocking IL-1, IL-33 and IL-36 Signaling with the Anti-IL1RAP Antibody mCAN10 Ameliorates Inflammation and Fibrosis in Preclinical Models of Systemic Sclerosis
  

  Presenting Author: Caitriona Grönberg, PhD – Cantargia AB
• 5:55 PM – 6:00 PM Eastern Time

  Q&A