14M132: Pathological Bone Remodeling in Rheumatic Diseases

Monday, November 14, 2022

12:00 PM – 1:00 PM Eastern Time

Location: Room 121

CE: 1

All of the relevant financial relationships listed for faculty have been mitigated.

Moderator(s)

IA

Iannis Adamopoulos, PhD

Division of Rheumatology, and Clinical Immunology
Holliston, MA, United States

Disclosure(s): No financial relationships to disclose

The overall goal of this session is to provide a general understanding of how bone tissue is affected during inflammatory conditions and appreciate the variation of the signals that contribute to pathological bone remodeling. The new advances in the field in the regulation of bone remodeling will be summarized by a didact lecture delivered by an authority in the field (Peter Croucher (Cell 184, 1330–1347, March 4, 2021), as well as a couple of recent examples of cell metabolism in OA (Nat Commun. 2020 Jul 9;11(1):3427) and RA from (Drs Abu-Amer and Gravallese).

Learning Objectives:

Improve education for trainees, practicing rheumatologists and enhance their understanding of various factors and treatments that influence pathological bone remodeling in rheumatic diseases
Provide an update on the latest research in the field regarding osteoclasts and osteoclast regulation in arthritis

Presentations:

12:00 PM – 12:15 PM Eastern Time

A Live View on Transcortical Blood Flow and Antiviral Immune Response in Murine Bones
Speaker: Matthias Gunzer, PhD – University of Duisburg-Essen
12:15 PM – 12:20 PM Eastern Time

Q&A
12:20 PM – 12:35 PM Eastern Time

Inflammation and Metabolism Crosstalk in Osteoarthritis
Speaker: Yousef Abu-Amer, PhD, MSc – Washington University School of Med
12:35 PM – 12:40 PM Eastern Time

Q&A
12:40 PM – 12:55 PM Eastern Time

The Role of Type I Interferons in Bone
Speaker: Ellen Gravallese, MD – Brigham and Women's Hospital, Harvard Medical School
12:55 PM – 1:00 PM Eastern Time

Q&A