12S109: STATS BOOTCAMP I: Tools to Analyze Performance of Screening and Diagnostic Tests

Saturday, November 12, 2022

11:00 AM – 12:00 PM Eastern Time

Location: Room 120

CE: 1

All of the relevant financial relationships listed for faculty have been mitigated.

Moderator(s)

Becki Cleveland, PhD

University of North Carolina
Chapel Hill, NC, United States

Disclosure(s): No financial relationships with ineligible companies to disclose

How do I best compare the performance of a new, more cost-effective screening test of disease against the “gold standard?" Is there a benefit to including additional diagnostic criteria with regards to a certain diagnostic test? These are examples of the type of research questions that are best addressed by analyzing the performance of screening or diagnostic tests.

The performance and accuracy of screening and diagnostic tests are relevant not just to the average researcher, but also to a practitioner or clinician that might interact with testing procedures on a routine basis and may have some of these questions themselves, or might seek out the relevant literature for such answers.

Learning Objectives:

Identify research questions that require the use of statistical measures for test performance and accuracy
Consider common measures used to assess screening or diagnostic test performance, including: sensitivity, specificity, positive and negative predictive values, the ROC curve, and positive and negative likelihood ratios
Expand on the publication of these measures in the rheumatology literature and their application to clinical practice; consider best approaches during manuscript preparation (Standards for Reporting of Diagnostic Accuracy)
Explore power and sample size considerations for these measures during the grant proposal process

Presentations:

11:00 AM – 11:20 AM Eastern Time

An Overview of the Research Objectives, Statistical Measures, and Sample Size Considerations When Assessing the Performance of Screening and Diagnostic Tests
Speaker: Carolina Alvarez, MS – University of North Carolina at Chapel Hill
11:20 AM – 11:40 AM Eastern Time

Manuscript Considerations, Publications, and Clinical Practice Applications of Screening and Diagnostic Test Performance and Accuracy Measures
Speaker: Jinoos Yazdany, MD, MPH – UCSF
11:40 AM – 12:00 PM Eastern Time

Q&A