65 - The Global Landscape of Nonalcoholic Fatty Liver Disease: Results From the Global Burden of Disease Study, 1990-2019

Award: Outstanding Research Award in the Liver Category

Yichen Wang, MD¹, Mark M. Aloysius, MD, PhD², Bing Chen, MD³, Howard Chung, MD⁴, Beishi Zheng, MD⁵, Tian Li, MD⁶, Xin Zheng, DO⁷, Yuntao Zou, MD⁸, Xiaoquan Huang, MD^9
1Trinity Health of New England, Springfield, MA; ²The Wright Center for Graduate Medical Education, Geisinger Commonwealth School of Medicine, ATSU-SOMA, Scranton, PA; ³New York University School of Medicine, New York, NY; ⁴New York University School of Medicine, Brooklyn, NY; ⁵Woodhull Medical and Mental Health Center, Brooklyn, NY; ⁶State University of New York Downstate Medical Center, Brooklyn, NY; ⁷Loma Linda University Medical Center, Loma Linda, CA; ⁸Saint Peter's University Hospital, New Brunswick, NJ; ⁹Zhongshan Hospital of Fudan University, Shanghai, Shanghai, China

Introduction: Nonalcoholic fatty liver disease (NAFLD) is causing an emerging global epidemic. The global burden of disease (GBD) study estimates the burden of NAFLD in 203 countries and geographic areas across the world, providing a unique opportunity to understand the landscape of this disease.

Methods: Prevalence, mortality, and disability-adjusted life years (DALYs) of NAFLD from 1990 to 2019 by region and country in all sex and age groups were collected from the Global Health Data Exchange (GHDx) results tool (Available from http://ghdx.healthdata.org/gbd-results-tool). DALYs are the sum of years lost due to premature death and years lived with disability. The socio-demographic index (SDI) categorizes countries and geographic areas by development (low, low-middle, middle, high-middle, and high).

Results: Between 1990 to 2019, the global prevalence of NAFLD increased from 10.9% to 16.6% (increased by 52.6%; linear regression beta-coefficient 0.2, P < .001). In 2019, an estimated 1.3 billion people were affected by NAFLD worldwide. Mortality attributed to NAFLD increased from 93,000 to 169,000. DALYs of NAFLD increased from 2.7 million years to 4.4 million years. Significant uptrends were observed in all SDI regions, more prominent in the middle SDI regions (Table 1). Changes in the prevalence of NAFLD by countries are depicted in Figure 1. All but three countries demonstrated an increase in the prevalence of NAFLD. More notable increases (≥10%) were mostly observed in North African and Middle Eastern countries.

Discussion: NAFLD's prevalence increased by more than 50% globally from 1990 to 2019. The mortality and DALYs also increased. The increase in NAFLD prevalence is more prominent in countries with middle SDI and countries in North African and Middle Eastern regions, possibly due to changes in lifestyle in these areas over the past 30 years.




Disclosures:


Yichen Wang, MD¹, Mark M. Aloysius, MD, PhD², Bing Chen, MD³, Howard Chung, MD⁴, Beishi Zheng, MD⁵, Tian Li, MD⁶, Xin Zheng, DO⁷, Yuntao Zou, MD⁸, Xiaoquan Huang, MD⁹, 65, The Global Landscape of Nonalcoholic Fatty Liver Disease: Results From the Global Burden of Disease Study, 1990-2019, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.