A0474 - Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With History of Alcohol Use Disorder (AUD): Retrospective Study Using NIS (2016 – 2019)

Sunday, October 23, 2022

5:00 PM – 7:00 PM ET

Location: Crown Ballroom

Presenting Author(s)

Noor Mualla, MD

Geisinger
Scranton, PA

Noor Mualla, MD¹, Sriram B. Chowdary, MD², Dhruv Lowe, MD², Abhinav Goyal, MD², Soohwan Chun, MD¹, Kishore Kumar, MD², Divey Manocha, MD², Duane Deivert, MD², Anil Singh, MD³, Rahul Dalavai, MBBS¹
¹Geisinger, Scranton, PA; ²Geisinger Health System, Scranton, PA; ³Geisinger Northeast Program, Scranton, PA

Introduction: Liver is the most common site for intra-abdominal abscess. Pyogenic liver abscess is more common in men compared to women. Risk factors include diabetes mellitus and chronic hepatobiliary disease. Alcohol abuse is known to cause bone marrow suppression and compromised immune system. Limited data are available regarding clinical outcomes in patients with history of alcohol use disorder who are admitted with pyogenic liver abscess.

Methods: Using National Inpatient Sample databases from 2016 to 2019. We identified patients presenting with pyogenic liver abscess, the population were then divided based on the presence and absence of alcohol use disorder using appropriate ICD-10-CM/PCS codes. STATA 16.0 software was used for the analysis. Pearson’s Chi-Square test was used to analyze categorical variable, whereas the student t-test was used to analyze continuous variables. Univariate and multivariate logistic regression was used to adjust for potential confounders. Primary outcome was in hospital mortality due to Pyogenic liver abscess in patients with alcohol use disorder.

Results: Amongst total of 19,830 patients admitted with pyogenic liver abscess, 1,090 patients had history of alcohol use disorder and 18,740 patients did not. Both groups consisted predominantly of white male patients. Mean LOS was higher in alcohol use disorder group (8±6.08 days) than in non-alcohol use disorder group (7.35±6.34 days ) (P=< 0.001 ). Mean total hospitalization charges were higher in AUD group ($ 20,968) than in the non-AUD group ($ 18,994) (P= < 0.001)

Discussion: Patient with Pyogenic liver abscess with alcohol use disorder history had higher resource utilization, but less odds of mortality.

	PLA WITH AUD, N(%)	PLA WITHOUT AUD, N(%)	P value
Total	1090(8.92)	18740(91.07)
Primary Outcome	OR	95CI	P value
Mortality	0.511	0.067 - 3.86	< 0.001
Secondary Outcomes	Mean	Mean	P value
LOS(days)	8+/-6.08	7.35+/-6.34	< 0.001
Charges(US$)	20968	18994	< 0.001
Demographics
Mean Age	57.65+/- 11.45	61.47+/-15.65
Female(%)	205(18.81)	7404(41)

Table: IN-PATIENT OUTCOME COMPARISON OF PATIENTS WITH HISTORY OF ALCOHOL USE DISORDER PRESENTING WITH PYOGENIC LIVER ABSCESS

Disclosures:

Noor Mualla indicated no relevant financial relationships.

Sriram Chowdary indicated no relevant financial relationships.

Dhruv Lowe indicated no relevant financial relationships.

Abhinav Goyal indicated no relevant financial relationships.

Soohwan Chun indicated no relevant financial relationships.

Kishore Kumar indicated no relevant financial relationships.

Divey Manocha indicated no relevant financial relationships.

Duane Deivert indicated no relevant financial relationships.

Anil Singh indicated no relevant financial relationships.

Rahul Dalavai indicated no relevant financial relationships.

Noor Mualla, MD¹, Sriram B. Chowdary, MD², Dhruv Lowe, MD², Abhinav Goyal, MD², Soohwan Chun, MD¹, Kishore Kumar, MD², Divey Manocha, MD², Duane Deivert, MD², Anil Singh, MD³, Rahul Dalavai, MBBS¹. A0474 - Outcomes of Pyogenic Liver Abscess (PLA) on Mortality and Hospitalization Cost Amongst Patients With History of Alcohol Use Disorder (AUD): Retrospective Study Using NIS (2016 – 2019), ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.