D0011 - Impact of Smoking Cessation Attempts in Reducing Low Bone Density Disease in Chronic Pancreatitis

Vibhu Chittajallu, MD¹, Arjun Chatterjee, MD², Jaime Abraham Perez, PhD³, Prabhleen Chahal, MD^4
1University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH; ²Cleveland Clinic Foundation, Cleveland, OH; ³University Hospitals Clinical Research Center, Cleveland, OH; ⁴Cleveland Clinic, Cleveland, OH

Introduction: Patients with chronic pancreatitis are at increased risk of low bone density, and tobacco smoking is an independent risk factor for the development of low bone density in this patient population. We aimed to determine if smoking cessation attempts would affect the risk of low bone density in chronic pancreatitis patients.

Methods: We conducted a retrospective cohort study utilizing TriNetX, which is a global federated health research network providing access to electronic medical records across 59 large healthcare organizations. Utilizing ICD-10 codes, we identified chronic pancreatitis patients with tobacco smoking history and divided them into two cohorts of smoking cessation and no smoking cessation. Smoking cessation attempt was defined as a prescription for varenicline/bupropion or a smoking cessation counseling visit. Propensity score matching was performed for demographics and medications (pancreatic enzyme replacement, calcium, and Vitamin D). Outcomes included osteoporosis, malnutrition, calcium deficiency, Vitamin D deficiency, and mortality. For continuous data, we performed independent t-tests. For categorical data, we performed chi-square tests.

Results: Of chronic pancreatitis patients with tobacco smoking history, we identified 9056 patients with smoking cessation attempts (Cohort 1) and 56,662 patients with no smoking cessation attempts (Cohort 2). After propensity score matching, 9,000 patients were accounted for in each group (Table 1). Reviewing one-year outcomes of these patients after propensity score matching, no difference in osteoporosis (OR 1.031, 95% CI 0.906-1.173) and calcium deficiency (OR 1, 95% CI 0.416-2.404) was noted between each cohort. 1,149 patients in Cohort 1 Vitamin D deficiency compared to 849 patients in Cohort 2 (OR 1.405, 95% CI 1.279-1.543). Malnutrition was seen in 1,012 patients in Cohort 1 and 1,672 patients in Cohort 2 (OR 0.555, 95% CI 0.510-0.604). One-year mortality noted 486 deaths in Cohort 1 and 772 deaths in Cohort 2 (OR 0.608, 0.541-0.684) (Table 2).

Discussion: Smoking cessation attempts in chronic pancreatitis patients with smoking histories are associated with one-year decreased risk of mortality and malnutrition. Further attempts to provide smoking cessation options to these patients for improved outcomes.




Disclosures:


Vibhu Chittajallu, MD¹, Arjun Chatterjee, MD², Jaime Abraham Perez, PhD³, Prabhleen Chahal, MD⁴. D0011 - Impact of Smoking Cessation Attempts in Reducing Low Bone Density Disease in Chronic Pancreatitis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.