B0494 - Diabetes as a Risk Factor of Liver Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease

Artemis Trikola, MD¹, Basilios Papastergiou, MD¹, Maria Mela, MD¹, Angeliki Christidou, MD¹, Aikaterini Mountaki, MD¹, Kanellos Koustenis, MD¹, Christos Veretanos, MD¹, Lazaros Karaouzas, MD¹, Athanasia Paparizou, MD¹, Konstantinos Arvanitis, MD¹, Emmanouel Archavlis, MD¹, Konstantina Katopodi, MD¹, Nikolaos Viazis, MD¹, Gerassimos J. Mantzaris, MD, PhD^2
1Evangelismos General Hospital, Athens, Attiki, Greece; ²Evangelismos-Polykliniki’ General Hospital, Athens, Attiki, Greece

Introduction: Non-alcoholic liver disease (NAFLD) ranks first in the prevalence among liver diseases, affecting 20-30% of the population worldwide. Type 2 diabetes mellitus (T2DM) commonly co-exists with NAFLD and may act synergically to drive adverse outcomes. We aimed to compare the characteristics and severity of liver disease between diabetic and non-diabetic patients with NAFLD, in a tertiary referral center in Greece.

Methods: Data including demographics, blood results and liver stiffness measurements (LSM) of consecutive NAFLD patients presenting to the hepatology outpatient clinic were retrospectively reviewed. LSM and FIB-4 measurements were used to non-invasively assess the severity of NAFLD.

Results: Ninety-eight patients were included (54.3% females, mean 60.4±15 years, 51.8% cirrhosis) of whom 64 (65.3%) were non-diabetics and 34 (34.6%) were diabetics. When compared to the non-diabetic group, diabetic patients were more frequently females (67.2% vs 46.2%, p=0.07), older (65.8 vs 54.6 years, p=0.005) and had lower ALT levels (25.2 vs 60.2IU/l, p=0.04). Contrarily, AST levels (39.6 vs 51IU/l, p=0.26), γ-GT (99.3 vs 102.1IU/l, p=0.95) and BMI (35.6 vs 34.6 Kg/m²) were not significantly different between the two groups. Regarding to severity of NAFLD, diabetic patients exhibited more advanced fibrosis, showing higher mean LSM (21.9 vs 11.9kPa, p=0.01) and FIB-4 (4.1 vs 2.2, p=0.01) values. The prevalence of cirrhosis ( >11.5kPa by LSM) was significantly higher in diabetic compared to non-diabetic patients (75% versus 41.3%, p=0.01). By multivariate analysis, advancing age (OR=1.04, 95%CI: 1.00-1.08; p =0.03) and T2DM (OR= 6.45, 95%CI: 1.80-23.03; p=0.004) were independently associated with cirrhosis.

Discussion: Our findings underline the importance of T2DM as a predisposing factor correlating with the severity of liver fibrosis in patients with NAFLD.


Disclosures:


Artemis Trikola, MD¹, Basilios Papastergiou, MD¹, Maria Mela, MD¹, Angeliki Christidou, MD¹, Aikaterini Mountaki, MD¹, Kanellos Koustenis, MD¹, Christos Veretanos, MD¹, Lazaros Karaouzas, MD¹, Athanasia Paparizou, MD¹, Konstantinos Arvanitis, MD¹, Emmanouel Archavlis, MD¹, Konstantina Katopodi, MD¹, Nikolaos Viazis, MD¹, Gerassimos J. Mantzaris, MD, PhD². B0494 - Diabetes as a Risk Factor of Liver Fibrosis in Patients With Non-Alcoholic Fatty Liver Disease, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.