D0134 - An Uncommon Cause for Common Symptoms of Abdominal Pain and Diarrhea: A Case Report of Human Intestinal Spirochetosis in an Immune-Competent Patient
Aireen Agulto, MD1, Faisal Bukeirat, MD1, Tahan Veysel, MD2, Harleen K. Chela, MD3, Feng Yin, MD, PhD2 1University of Missouri Health Care, Columbia, MO; 2University of Missouri, Columbia, MO; 3University of Missouri-Columbia, Columbia, MO
Introduction: Abdominal pain, diarrhea, and weight loss are common but non-specific symptoms that can lead to extensive evaluation for the etiology, e.g., malignancy, infection, or IBS. While the incidence of neuroendocrine tumors (NETs) is increasing, those of the GI tract are rare, and even rarer is human intestinal spirochetosis (HIS). Here, we present an unusual case of an immune-competent patient incorrectly diagnosed with a NET and found to have HIS.
Case Description/Methods: A 54-year-old female with IBS-D and GERD on PPI was referred for one year of abdominal pain, diarrhea, and weight loss. A year ago, she had a cholecystectomy and made dietary changes without resolution. Prior labs collected showed elevated gastrin and somatostatin but normal VIP and urine 5-HIIA, concerning for NET. Prior double balloon enteroscopy did not locate any bowel lesions. CT A/P showed 1cm focus of high attenuation/enhancement in the ileum (image A). Chromogranin A levels were elevated. PET Dotatate scan performed two weeks later did not show any abnormal lesions (image B) despite persistent symptoms. Surgical oncology recommended repeat gastrin levels off PPI, and she was given colestipol for diarrhea with minor relief. Repeat gastrin levels were normal, and EGD/colonoscopy performed two months later was endoscopically unremarkable with no lesions seen after 30 cm intubation of the TI. However, random colon biopsies showed a focal fuzzy basophilic layer of organisms at luminal surface, highlighted by Warthin-Starry stain, suggestive of intestinal spirochetosis (images C-D). She was prescribed a two-week course of metronidazole with eventual full relief of diarrhea. She was referred to ID for further management.
Discussion: Human intestinal spirochetosis is likely underestimated due to its rarity, especially in heterosexual and immune-competent patients, and suboptimal diagnostic methods. Thus, a subset of IBS patients with diarrhea can often be misdiagnosed for years, especially if they are not immunocompromised. Long-term PPI use is also very prevalent, and one long-standing concern is PPI-induced gastrin elevation secondary to hypoacidity, which confounded our results. Ultimately, diagnosis is confirmed by histopathology and resolution of symptoms with metronidazole. Our case highlights the unusual diagnosis in an immune-competent patient with a puzzling work up.
Figure: Image A: CT A/P (coronal) showing 1 cm focus of high attenuation/enhancement along the dependent aspect of an ileal bowel loop (white arrow), which may represent hyperdense enteric contents versus an enhancing lesion, but is suboptimally evaluated secondary to lack of precontrast images.
Image B: No abnormal Dotatate-avid lesions.
Image C-D: H&E slide images of colonic biopsies (left, pending) and Warthin-Starry stain showing focal fuzzy basophilic layer of organisms at luminal surface of colonic epithelium .
Disclosures:
Aireen Agulto indicated no relevant financial relationships.
Faisal Bukeirat indicated no relevant financial relationships.
Tahan Veysel — NO DISCLOSURE DATA.
Tahan Veysel indicated no relevant financial relationships.
Harleen Chela indicated no relevant financial relationships.
Feng Yin indicated no relevant financial relationships.
Aireen Agulto, MD1, Faisal Bukeirat, MD1, Tahan Veysel, MD2, Harleen K. Chela, MD3, Feng Yin, MD, PhD2. D0134 - An Uncommon Cause for Common Symptoms of Abdominal Pain and Diarrhea: A Case Report of Human Intestinal Spirochetosis in an Immune-Competent Patient, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.
