D0477 - Low Insulin-Like Growth Factor 1 as a Predictor of Poor Prognosis in Liver Cirrhosis

I Ketut Mariadi, MD¹, Reza Surahmanto, ¹, I. Dewa Nyoman Wibawa, MD, PhD^2
1Udayana University, Denpasar, Bali, Indonesia; ²University of Udayana, Denpasar, Bali, Indonesia

Introduction: Insulin-like growth factor 1 (IGF1) disturbances are observed in liver cirrhosis. IGF1 deficiency resulting variety of metabolic complications. Changes in IGF1 concentrations, depending on the clinical stage of liver cirrhosis. This study aimed to prove the role of IGF1 as predictor for prognosis in Liver cirrhosis.

Methods: A cross-sectional analytic study was performed in liver cirrhosis patients. Serum IGF-1 levels were measured using the Bioassay Technology with the Enzyme-Linked Immunosorbent Assay (ELISA) method. The results were expressed in units of ng/ml. Patient's prognosis determine using the Child-Pugh-Turcotte score (CTP). CTP B-C are assigned a poor prognosis with a mortality risk of 20-55% at 1 year. The cut off for IGF1 is determined by the ROC curve. Data were analyzed using computer software

Results: The research subjects consisted of 62 males (80.5%) and 15 females (19.5%), with a mean age of 47.64 ± 7.47 years. Based on CTP scores, 32 (41.5%) samples had CTP B-C and 45 (58.4%) had CTP A. The mean IGF1 levels were 2.06 ± 1.08 ng/mL (0.46 ng/ml -5.73 ng/ ml). The mean CTP score was 6.84 ± 2.18 (5-13). The mean IGF1 in CTP A and BC was 2.43 ± 1.08 ng/mL and 1.54 ± 0.82 ng/mL (p< 0.001; 95% CI 0.43-1.34). Based on the ROC curve, IGF1 levels greater than or equal to 1.62 ng/mL were defined as high levels. There was a significant relationship between IGF1 levels and CTP scores (p< 0.001; OR=6.7, 95%CI: 2.4-18.4). Low IGF1 levels are associated with poor prognosis, liver cirrhosis patients with IGF1 values less than 1.62 ng/mL are 6.7 times more likely to have a 20-55% mortality risk at 1 year.

Discussion: Mean IGF1 levels were significantly lower in CTP B-C than in CTP A, and low IGF1 levels suggest a possibly poorer prognosis in patients with liver cirrhosis. IGF1 concentration decreased with the severity of cirrhosis (Child–Pugh score), reaching significantly low values in class C. The CTP score has been validated as a predictor of postoperative mortality after portocaval shunt surgery and predicts mortality risk associated with other major operations. The CTP score can help predict all-cause mortality risk and development of other complications from liver dysfunction, such as variceal bleeding, as well. Reported the overall mortality for these patients at 1 year was 0% for Child class A, 20% for Child class B, and 55% for Child class C. Based on the results of this study, it can be concluded that low IGF1 is a predictor of poor prognosis in patients with liver cirrhosis.


Disclosures:


I Ketut Mariadi, MD¹, Reza Surahmanto, ¹, I. Dewa Nyoman Wibawa, MD, PhD². D0477 - Low Insulin-Like Growth Factor 1 as a Predictor of Poor Prognosis in Liver Cirrhosis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.