D0685 - 10-Year Epidemiological Trends of Eosinophilic Gastritis and Eosinophilic Gastroenteritis

Tuesday, October 25, 2022

10:00 AM – 12:00 PM ET

Location: Crown Ballroom

Has Audio

Presenting Author(s)

Aun R. Shah, MD, MRCP

University of Nebraska Medical Center
Omaha, NE

Aun R. Shah, MD, MRCP¹, Ishani Shah, MD², Rubab Ali, MD³, Sarah Malik, MBBS¹, Alexander T. Hewlett, DO¹
¹University of Nebraska Medical Center, Omaha, NE; ²Beth Israel Deaconess Medical Center, Boston, MA; ³Clarkson Family Medicine, Omaha, NE

Introduction: Eosinophilic gastritis (EG) and eosinophilic gastroenteritis (EGE) are rare entities. There is limited epidemiological data available for these disorders. The estimated prevalence of EG and EGE are 6.3/100,000 and 8.4/100,000 respectively in the general population. A large cohort study published in 2019, increasing prevalence rates for these disorders. In this study we sought to identify the epidemiological trends of EG and EGE from a large US population-based sample.

Methods: We utilized the National Inpatient Sample (NIS) database, to identify trends of EG and EGE. Patients with a principal or secondary diagnosis of EG or EGE were identified from the years 2008 to 2018 using ICD-9 and ICD-10 codes. Annual prevalence of EG and EGE was calculated as well as epidemiological and healthcare utilization trends. Healthcare resource utilization measures included in the study were length of stay (LOS), hospital bed size, median household income, hospital region, primary payer and total hospitalization charges.

Results: From 2008 to 2018, a total of 6,027 patients with a diagnosis of EG or EGE were identified. The unweighted prevalence of EG/EGE during this 10-year period was approximately 8.61/100,000 patients. There was an increase in the rates of diagnosis annually from 207 to 685 patients over the study period. There was a female preponderance in the population which did not significantly change [p 0.35]. The mean age was 47.8 years [SEM: 0.6 years] and there was no significant variation in age distribution over 10 years [p 0.67]. Demographic trends are summarized in Figure 1. There was no significant change in trends for hospital type, median household income, primary payer, length or stay or patient race. Healthcare utilization trends are summarized in Table 1. There was however a significant increase in hospital charges from 2008 to 2018 [p 0.04]. The rates of diagnosis increased significantly from 2008 to 2018 in the South and West hospital regions when compared to other regions [p 0.01].

Discussion: The prevalence of EG and EGE remains rare in the US but it continues to steadily rise. This is associated with increasing healthcare utilization costs. The prevalence is significantly increasing in the South and West regions particularly. Further study is needed to assess causes for increasing prevalence and changing epidemiology of EG and EGE.

Figure: Figure 1: Demographic and Prevalence trends

Year	2008	2009	2010	2011	2012	2013	2014	2015	2016	2017	2018	p-value

Race (%)												0.54
White	74.35	75.64	70.49	75.25	71.55	77.89	68.82	70.71	58.97	67.44	69.12
Black	6.83	9.04	16.31	5.2	8.62	7.37	12.9	14.14	17	13.18	8.82
Hispanic	12.62	10.18	6.25	8.76	12.07	8.42	11.83	8.08	16.2	12.4	9.56
Asian/Pacific islander	6.2	1.14	4.05	8.76	3.45	3.16	3.23	6.06	5.9	4.65	10.29
Native American	0	2	0.65	1.02	1.72	0	0	0	0	0	1.47
Other	0	1.9	2.15	1.01	2.59	3.16	3.23	1.01	1.71	2.33	0.74
Primary Expected Payer (%)												0.06
Medicare	38.21	25.85	21.32	27.37	28.57	38	28.43	31.07	31.71	36.84	25.55
Medicaid	14.74	6.66	15.94	10.87	10.08	7	14.71	20.39	15.45	18.8	17.52
Private insurance	44.38	51.29	53.63	46.6	54.62	46	53.92	43.69	44.72	39.85	47.45
Self-pay	2.67	11.06	6.12	6.61	5.88	8	1.96	2.91	4.88	3.76	5.11
No charge	0	0	0.78	1.16	0	1	0	0.97	0	0	0
Other	0	5.02	2.22	7.38	0.84	0	0.98	0.97	3.25	0.76	4.38
Hospital Region (%)												0.01
Northeast	25.85	26.83	22.47	13.79	29.41	25.74	12.75	19.42	21.15	20.16	15.33
Midwest	29.85	22.86	15.13	26.51	12.61	19.8	32.35	23.3	30.89	21.64	25.55
South	18.52	3848	46.56	30.54	36.13	35.64	35.29	38.83	28.46	26.87	30.66
West	25.76	11.83	15.85	29.16	21.85	18.81	19.61	18.45	19.51	31.34	28.47
Hospital Type (%)												0.5
Rural	16.03	12.59	12.47	12.55	15.13	9.9	19.61	14.56	17.07	17.16	23.36
Non-teaching urban	27.52	20.18	24.04	17.37	22.69	21.78	19.61	20.39	27.64	25.37	28.47
Teaching urban	56.45	67.23	63.49	70.08	62.18	68.32	60.78	65.05	55.28	57.46	48.18
Median Household Income National Quartile for Patient ZIP Code (%)												0.19
$1-24,999	14.21	19.2	19.61	18.69	15.52	20.41	28.71	27.72	20.66	23.26	23.7
$25,000-34,999	30.39	20.54	25.02	21.06	20.69	17.35	26.73	28.71	28.93	18.6	22.96
$35,000-44,999	14.71	33.55	26.57	35.14	22.41	27.55	19.8	18.81	26.45	27.91	27.41
45,000 or more	40.69	26.71	28.8	25.11	41.38	34.69	24.75	24.76	23.97	30.23	25.93

Table: Table 1: Healthcare utilization trends

Disclosures:

Aun Shah indicated no relevant financial relationships.

Ishani Shah indicated no relevant financial relationships.

Rubab Ali indicated no relevant financial relationships.

Sarah Malik indicated no relevant financial relationships.

Alexander Hewlett indicated no relevant financial relationships.

Aun R. Shah, MD, MRCP¹, Ishani Shah, MD², Rubab Ali, MD³, Sarah Malik, MBBS¹, Alexander T. Hewlett, DO¹. D0685 - 10-Year Epidemiological Trends of Eosinophilic Gastritis and Eosinophilic Gastroenteritis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.