Poster Session E - Tuesday Afternoon
Category: Biliary/Pancreas
Shaharyar Zuberi, MD
Beth Israel Deaconess Medical Center, Harvard Medical School
Boston, MA
| No diabetes N=271 | Pre-existing diabetes N=99 | Early-onset diabetes (< 2 years) N=51 | Late-onset diabetes ( >2years) N=29 | P-value |
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Mean age in years (SD) | 57.3 (16.0) | 62.5 (12.8) | 54.1 (13.5) | 61.9 (11.5) | 0.002 |
Mean age at diagnosis of CP (SD) | 45.0 (16.2) | 53.0 (14.5) | 41.2 (15.5) | 47.8 (13.4) | < 0.001 |
Female sex (%) | 133 (49.6%) | 43 (43.4%) | 22 (43.1%) | 13 (44.8%) | 0.659 |
White race (%) | 201 (75.6%) | 71 (71.7%) | 34 (66.7%) | 24 (82.8%) | 0.34 |
Mean number of follow up years in pancreas center | 7.84 (5.36) | 7.86 (6.68) | 8.74 (5.49) | 12.1 (5.05) | 0.004 |
Etiology of CP: |
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| < 0.001 |
Alcohol | 86 (31.7%) | 32 (32.3%) | 23 (45.1%) | 9 (31.0%) | |
Genetic | 8 (2.95%) | 2 (2.02%) | 3 (5.88%) | 1 (3.45%) | |
Idiopathic | 88 (32.5%) | 21 (21.2%) | 8 (15.7%) | 6 (20.7%) | |
Smoking | 69 (25.5%) | 36 (36.4%) | 15 (29.4%) | 11 (37.9%) |
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Other | 20 (7.38%) | 8 (8.08%) | 2 (3.92%) | 2 (6.90%) |
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History of recurrent acute pancreatitis (%) | 214 (78%) | 69 (69.6%) | 35 (68.6%) | 21 (72.4%) | 0.943 |
Chronic abdominal pain (%) | 205 (79.2%) | 80 (80.8%) | 48 (94.1%) | 23 (79.3%) | 0.094 |
Splanchnic vein thrombosis (%) | 22 (8.43%) | 15 (15.3%) | 7 (13.7%) | 8 (27.6%) | 0.013 |
Pseudocyst (%) | 81 (30.9%) | 39 (39.8%) | 25 (49.0%) | 14 (48.3%) | 0.027 |
Biliary obstruction (%) | 30 (11.7%) | 22 (22.7%) | 9 (17.6%) | 7 (24.1%) | 0.031 |
Vitamin D deficiency (%) | 78 (32.1%) | 45 (51.7%) | 23 (48.9%) | 20 (83.3%) | < 0.001 |
Mean Hba1c Level (SD) | 5.11 (1.15) | 7.71 (1.38) | 8.02 (1.61) | 7.66 (0.98) | < 0.001 |
On insulin (%) | 0 | 48 (48.4%) | 40 (78.4%) | 19 (65.5%) | < 0.001 |
Pancreatic malignancy (%) | 10 (3.88%) | 4 (4.08%) | 3 (5.88%) | 0 (0.00%) | 0.709 |
Exocrine pancreatic insufficiency (%) | 144 (53.1%) | 65 (65.7%) | 36 (70.6%) | 21 (72.4%) | 0.014 |
Opioid use (%) | 116 (43.9%) | 54 (55.1%) | 33 (64.7%) | 13 (44.8%) | 0.024 |
Non-opioid controlled medications (%) | 63 (24.0%) | 32 (32.7%) | 17 (33.3%) | 10 (34.5%) | 0.220 |
Gabapentinoid use (%) | 114 (43.5%) | 47 (48.0%) | 34 (66.7%) | 17 (60.7%) | 0.012 |
Medical marijuana use (%) | 19 (7.66%) | 8 (8.60%) | 9 (18.8%) | 3 (10.7%) | 0.120 |
Mean number of flares requiring hospitalization (SD) | 2.02 (3.42) | 2.55 (3.18) | 3.06 (3.44) | 2.41 (3.39) | 0.202 |
Recurrent ED visits (%) | 15 (5.75%) | 9 (9.18%) | 4 (8.00%) | 2 (6.90%) | 0.617 |
Mean total abdominal imaging since diagnosis (SD) | 4.28 (3.60) | 5.64 (4.53) | 7.49 (6.43) | 7.28 (4.52) | < 0.001 |
Celiac block for pain (%) | 27 (10.3%) | 12 (12.2%) | 17 (33.3%) | 6 (21.4%) | < 0.001 |
Pancreatic surgery for pain (%) | 22 (8.43%) | 9 (9.18%) | 15 (29.4%) | 13 (46.4%) | < 0.001 |