E0499 - Gender and Racial Disparities in NAFLD With Outcomes in the United States

Navalok Sharma Ghimire, MBBS¹, Uchit Thapa, MBBS¹, Harshith Thyagaturu, MD¹, Prakash Poudel Jaishi, MBBS², Parikshya Giri Rijal, MBBS¹, Samir Jha, MD³, Lintha Shah, MBBS¹, Amna Shaukat, MBBS¹, Anish Paudel, MD⁴, Hira Hanif, MD⁵, Suravi Khanal, MBBS⁶, Aashish K. Singh, MBBS⁷, Ansu Karki, MBBS¹, Anjeela Kadel, MBBS^1
1Bassett Medical Center, Cooperstown, NY; ²Al Kamil Health Center, Al Kamil, Janub ash Sharqiyah, Oman; ³Beth Israel Deaconess Medical Center, Boston, MA; ⁴Reading Hospital Tower Health, West Reading, PA; ⁵Reading Tower Health, West Reading, PA; ⁶Manipal College of Medical Sciences, Pokhara, Gandaki, Nepal; ⁷APPL, Nongpoh, Meghalaya, India

Introduction: Different races and genders have been known to have a different prevalence of Non-alcohol fatty
liver disease (NAFLD). We conducted a nationwide study with National Inpatient Sample (NIS)
database to identify the prevalence of NAFLD among races and gender, along with their
associated mortality.

Methods: We used the 2019 NIS database to identify all adults ( >18 years) diagnosed with NAFLD
using the relevant ICD-10-CM codes. Gender and racial distribution amongst NAFLD patients
were obtained using the variables available within the database. We conducted univariate screen
and multivariate logistic regression to adjust for potential patient and hospital level confounders
to evaluate if there is any association of racial or gender groups with mortality. All statistical
analyses were carried out using Stata 17.0 software.

Results: A total of 532,485 adult NAFLD patients were identified in the study. The racial distribution
amongst this NAFLD group included: Whites (68.3%), Blacks (9.4%), Hispanics (16%),
Asian/pacific islanders (2.3%), Native Americans (1%), and others (3.1%). NAFLD patients
within our study were predominantly female with 54.5% and 45.6% males. On multivariate
analysis, we found that the odds of mortality in blacks were lower as compared to whites [OR
0.75 (0.63-0.89); p=0.001]. Whereas there was no difference in odds of mortality among
different genders.

Discussion: Our study shows a significantly higher prevalence of NAFLD in Whites followed by Hispanics
and Blacks respectively. Interestingly, in our study, blacks were found to have lower odds of
mortality compared to whites. Studies have found a higher rate of rs738409 SNP (G-allele)
mutation in whites compared to blacks. This has been linked to severe fibrosis and increased
mortality in whites with NAFLD possibly due to the development of cirrhosis and hepatocellular
carcinoma. Also, we found more females with NAFLD in 2019. Our study findings of higher
NAFLD prevalence in females and lower odds of mortality in blacks compared to white are
based on a one-year analysis and needs more extensive studies to identify potential causes for the
observed differences.


Disclosures:


Navalok Sharma Ghimire, MBBS¹, Uchit Thapa, MBBS¹, Harshith Thyagaturu, MD¹, Prakash Poudel Jaishi, MBBS², Parikshya Giri Rijal, MBBS¹, Samir Jha, MD³, Lintha Shah, MBBS¹, Amna Shaukat, MBBS¹, Anish Paudel, MD⁴, Hira Hanif, MD⁵, Suravi Khanal, MBBS⁶, Aashish K. Singh, MBBS⁷, Ansu Karki, MBBS¹, Anjeela Kadel, MBBS¹. E0499 - Gender and Racial Disparities in NAFLD With Outcomes in the United States, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.