A0376 - Burden and Impact of Cannabis Use Disorder on Outcomes of IBD Patients With Alcohol Abuse: A National Inpatient Sample Analysis 2019

Yashwitha Sai Pulakurthi, MBBS¹, Praneeth Reddy Keesari, MBBS², Navya Sadum, MBBS³, Taherunnisa Rida, BS⁴, Ali Tariq Alvi, MD⁵, Vikash Kumar, MD⁶, Nikhila Appala, MBBS⁷, Jaswanth R. Jasti, MD⁸, Rewanth Katamreddy, MD⁹, Satya Sai Venkata Lakshmi Arepali, MBBS¹⁰, Mariam Ashfaque, MBBS¹¹, Rupak Desai, MBBS^12
1New York Medical College- Saint Michael's Medical Center, Newark, NJ; ²Staten Island University Hospital, Staten Island, NY; ³Kamineni Academy of Medical Sciences and Research Centre, Hyderabad, Telangana, India; ⁴University of Texas at Dallas, Plano, TX; ⁵HCA Florida Westside Hospital, Plantation, FL; ⁶The Brooklyn Hospital Center, Brooklyn, NY; ⁷Kasturba Medical College, Manipal, Karnataka, India; ⁸University of South Dakota Sanford School of Medicine, Vermillion, SD; ⁹Saint Michael's Medical Center, Newark, NJ; ¹⁰Apollo Institute of medical sciences and Research Center, Hyderabad, Telangana, India; ¹¹People University of Medical and Health Sciences, Nawabshah, Sindh, Pakistan; ¹²Independent Researcher, Atlanta, GA

Introduction: Alcohol use disorder can potentially trigger Inflammatory bowel disease (IBD) flare-ups. With increasing use of cannabis for symptomatic relief in IBD, the impact of its chronic/habitual use on IBD outcomes remains unclear. Therefore, in this study we aimed to assess the burden and impact of concomitant cannabis use disorder (CUD) on IBD patients with known alcohol abuse.

Methods: The National Inpatient Sample (2019) with relevant ICD-10 codes were used to identify Alcoholic Inflammatory Bowel Disease (IBD) patients and Cannabis Use Disorder (CUD). We compared demographics, comorbidities, and outcomes of alcoholic IBD patients with vs. without CUD. Primary endpoints were hospital outcomes [MACCE:all-cause mortality, acute myocardial infarction (MI), cardiac arrest and stroke], intestinal obstruction, colorectal cancer, colectomy, acute kidney injury[AKI], and sepsis) compared between CUD and non-CUD cohort among alcoholic IBD patients. Multivariable regression analyses were performed adjusting for demographics, hospital-level characteristics and relevant comorbidities.

Results: Of 11,140 hospitalizations with IBD and alcohol abuse, 1130 (10%) concomitantly had CUD. Majority of the CUD cohort was white, male and the median age at admission was 40 years (IQR 33- 51). Most of them were Medicaid enrollees (41.2%) and belonged to lower 2 median household income national quartiles (31.7, 31.2%) The CUD cohort had a lower rate of traditional cardiovascular risk factors and pulmonary comorbidities except higher rate of tobacco use disorder vs. non-CUD cohort. Rates of intestinal obstruction (aOR 1.80; 95%CI:O.75-4.29) (p=0.187) and colorectal cancer (aOR 1.42; 95% CI:0.37-5.54)(p=0.610) were high among the CUD cohort (Table 1). However, neither of them attained statistical significance.

Discussion: Despite a higher burden of cardiovascular disease risk factors, the CUD cohort had comparable outcomes/complications in alcoholic IBD patients vs. non CUD cohort. Future prospective studies are warranted to confirm and validate these findings focusing on mode, dose and duration of recreational/medicinal use of cannabis in IBD patients with rising prevalence of polysubstance use in the US.



Disclosures:


Yashwitha Sai Pulakurthi, MBBS¹, Praneeth Reddy Keesari, MBBS², Navya Sadum, MBBS³, Taherunnisa Rida, BS⁴, Ali Tariq Alvi, MD⁵, Vikash Kumar, MD⁶, Nikhila Appala, MBBS⁷, Jaswanth R. Jasti, MD⁸, Rewanth Katamreddy, MD⁹, Satya Sai Venkata Lakshmi Arepali, MBBS¹⁰, Mariam Ashfaque, MBBS¹¹, Rupak Desai, MBBS¹². A0376 - Burden and Impact of Cannabis Use Disorder on Outcomes of IBD Patients With Alcohol Abuse: A National Inpatient Sample Analysis 2019, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.