C0003 - Trends in the Incidence of Intrahepatic Cholangiocarcinoma Between 1990 and 2019 Stratified by Race, Ethnicity and Gender Among Pennsylvania Residents

Edward Bley, DO, Inimfon Jackson, MD, PhD, Michael Goldberg, DO, Claudia M. Dourado, MD
Albert Einstein Medical Center, Philadelphia, PA

Introduction: Research reports a rising incidence of intrahepatic cholangiocarcinoma (ICC) but recent trends and differences by race/ethnicity and gender have not been explored. Epidemiologic evidence is needed to enable clinicians better understand evolving trends, to inform prevention strategies and screening guidelines. We examined trends in the incidence of ICC among Pennsylvania residents between 1990 and 2019, stratified by age, gender, race, and stage at presentation.  

Methods: Repeated cross-sectional analyses were conducted among patients diagnosed with ICC between 1990-2019 in Pennsylvania using data from the Pennsylvania Department of Health Cancer Registry. Temporal trends with age adjusted incidence rates according to race/ethnicity, gender, age and stage at presentation were assessed using the Enterprise Data Dissemination Informatics Exchange (EDDIE).  

Results: 4,051 cases of invasive ICC were diagnosed between 1990 and 2019 (Table 1). The age adjusted incidence rate of ICC increased by a factor of 10, from 0.2 per 100,000 population in 1990 to 2.0 per 100,000 population in 2019 (Graph 1). The incidence rate was higher among those aged more than 40 years compared to those less than 40 years old (2.24 vs 0.04 per 100,000 population) and higher among males relative to females (1.15 vs 1.03 per 100,000 population). Incidence rate was also highest amongst Whites (1.14 per 100,000 population), compared to Asian/Pacific Islander (0.91 per 100,000 population), Blacks (0.76 per 100,000 population) and Hispanics (0.53 per 100,000 population). 31% of patients presented with stage III/IV disease while 28% presented with stage II disease. The rates per decade increased slightly from the 1990’s to the 2000’s (0.65 vs 0.74 per 100,000 population) before increasing drastically in the 2010’s to 1.83 per 100,000 population.  

Discussion: These results demonstrate significant increase in incidence rates of ICC in recent years. Five-year survival rates of ICC regardless of stage have been reported in other studies at 9%. Given this high mortality and rising incidence rates, clinicians may need to start considering possible screening strategies. Furthermore, other prevention and treatment approaches need to be investigated. 




Disclosures:


Edward Bley, DO, Inimfon Jackson, MD, PhD, Michael Goldberg, DO, Claudia M. Dourado, MD. C0003 - Trends in the Incidence of Intrahepatic Cholangiocarcinoma Between 1990 and 2019 Stratified by Race, Ethnicity and Gender Among Pennsylvania Residents, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.