D0004 - Comorbid Diabetes on Hospitalization Outcomes in Acute Pancreatitis

Simcha Weissman, DO¹, Makenna Allen, BS², Adarsh Vardhan Tangella, MBBS³, Suni Mol Iyyankutty, MBBS⁴, Gagan Kaur, MBBS¹, Sarah Ali, MBBS¹, Mayank Dineshbhai Kamani, ⁵, Mavis Lobo, MBBS¹, Tejaswee Mallela, MBBS⁶, Barbara M. Pimenta Fontenelle, ⁷, Seyma Bayram, MBBS¹, Georgemar Arana, MBBS¹, Raewon Kwon, MBBS¹, Hannah G. Terefe, BS⁸, Adam H. Bin Md Kamal, MD⁹, Anvesh Ravanavena, MBBS^1
1HMH-PMC, North Bergen, NJ; ²SGU, Hackensack, NJ; ³Andhra Medical College, Vizag, Chicago, IL; ⁴HMH-PMC, Orlando, FL; ⁵Teaching University Geomedi, Rajkot, Gujarat, India; ⁶Soochow University, Sayreville, NJ; ⁷Kazan State Medical University, Toronto, ON, Canada; ⁸St. George’s University School of Medicine, Great River, NY; ⁹University of Malaya, Kuala Lumpur, Kuala Lumpur, Malaysia

Introduction: Data on the association between comorbid diabetes mellitus (DM) and acute pancreatitis (AP) remain limited. Utilizing a large, nationwide database, we aimed to examine the impact of comorbid diabetes mellitus on patients admitted for acute pancreatitis.

Methods: This was a retrospective case-control study of adult patients with AP utilizing the National Inpatient Sample from 2015-2018, using ICD-10 codes. Hospitalization outcomes of patients admitted for AP with comorbid DM were compared to those without comorbid DM at the time of admission. The primary outcome was a mortality difference between the cohorts. Multivariate regression analysis was performed.

Results: 940,789 adult patients with AP were included, of which 256,330 (27.3%) had comorbid DM. Comorbid DM was associated with a 31% increased risk of inpatient mortality (aOR: 1.31; p=0.004), a 53% increased risk of developing sepsis (aOR: 1.53; p=0.002), increased hospital length of stay (LOS) (4.5 days vs. 3.7 days; p < 0.001), and hospital costs ($9934 vs. $8486; p < 0.001). Whites admitted for AP with comorbid DM were at a 49% increased risk of mortality as compared to Hispanics (aOR: 1.49; p < 0.0001).

Discussion: Comorbid DM appears to be a risk factor for adverse hospitalization outcomes in patients admitted for AP with male sex and race as additional risk factors. Future prospective studies are warranted to confirm these findings to better risk stratify this patient population.


Disclosures:


Simcha Weissman, DO¹, Makenna Allen, BS², Adarsh Vardhan Tangella, MBBS³, Suni Mol Iyyankutty, MBBS⁴, Gagan Kaur, MBBS¹, Sarah Ali, MBBS¹, Mayank Dineshbhai Kamani, ⁵, Mavis Lobo, MBBS¹, Tejaswee Mallela, MBBS⁶, Barbara M. Pimenta Fontenelle, ⁷, Seyma Bayram, MBBS¹, Georgemar Arana, MBBS¹, Raewon Kwon, MBBS¹, Hannah G. Terefe, BS⁸, Adam H. Bin Md Kamal, MD⁹, Anvesh Ravanavena, MBBS¹. D0004 - Comorbid Diabetes on Hospitalization Outcomes in Acute Pancreatitis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.