Poster Session D - Tuesday Morning
Category: IBD
Javier Zambrano, MD
AbbVie, Inc.
North Chicago, Illinois
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| Week 12 SF/APS Clinical Remission RZB 600 mg IV | Week 12 CDAI Clinical Remission RZB 600 mg IV | Week 12 CDAI Clinical Response RZB 600 mg IV | Week 12 Endoscopic Response RZB 600 mg IV | Week 12 Endoscopic Remission RZB 600 mg IV | Week 12 Ulcer-free Endoscopy RZB 600 mg IV | Week 52 SF/APS Clinical Remission RZB 360 mg SC | Week 52 CDAI Clinical Remission RZB 360 mg SC | Week 52 CDAI Clinical Response RZB 360 mg SC | Week 52 Endoscopic Response RZB 360 mg SC | Week 52 Endoscopic Remission RZB 360 mg SC | Week 52 Ulcer-free Endoscopy RZB 360 mg SC |
Induction Baseline Characteristics as Predictors of Response
Odds Ratio [95% CI] P-value | Colonic Disease Only | 1.436 [0.766, 2.693] P=0.260 | 1.653 [0.883, 3.094] P=0.116 | 1.448 [0.774, 2.709] P=0.247 | 5.178 [2.411, 11.123] P< 0.001 | 3.077 [1.425, 6.644] P=0.004 | 3.393 [1.510, 7.624] P=0.003 | 0.654 [0.265, 1.614] P=0.357 | 0.886 [0.357, 2.203] P=0.795 | 0.938 [0.378, 2.328] P=0.890 | 4.909 [1.468, 16.410] P=0.010 | 2.135 [0.722, 6.317] P=0.170 | 2.428 [0.731, 8.060] P=0.147 |
| Ileal-colonic Disease Only | 0.751 [0.411, 1.370] P=0.350 | 0.821 [0.451, 1.492] P=0.517 | 0.906 [0.506, 1.622] P=0.739 | 2.880 [1.379, 6.017] P=0.005 | 1.262 [0.590, 2.702] P=0.548 | 0.767 [0.331, 1.775] P=0.535 | 0.634 [0.263, 1.529] P=0.311 | 1.032 [0.426, 2.503] P=0.944 | 0.806 [0.333, 1.952] P=0.632 | 4.351 [1.318, 14.366] P=0.016 | 1.826 [0.627, 5.321] P=0.270 | 2.018 [0.617, 6.602] P=0.246 |
| Bio-Failure Status | 0.675 [0.423, 1.076] P=0.098 | 0.789 [0.495, 1.258] P=0.320 | 0.867 [0.540, 1.393] P=0.556 | 0.438 [0.271, 0.709] P< 0.001 | 0.597 [0.352, 1.013] P=0.056 | 0.570 [0.317, 1.026] P=0.061 | 0.425 [0.229, 0.787] P=0.006 | 0.373 [0.200, 0.698] P=0.002 | 0.426 [0.225, 0.805] P=0.009 | 0.443 [0.233, 0.844] P=0.013 | 0.444 [0.228, 0.863] P=0.017 | 0.295 [0.144, 0.606] P< 0.001 |
| Corticosteroid Use | 0.506 [0.321, 0.799] P=0.003 | 0.491 [0.313, 0.769] P=0.002 | 0.440 [0.283, 0.683] P< 0.001 | 0.742 [0.466, 1.181] P=0.208 | 0.786 [0.463, 1.334] P=0.372 | 0.891 [0.493, 1.609] P=0.701 | 0.443 [0.243, 0.805] P=0.008 | 0.331 [0.178, 0.613] P< 0.001 | 0.374 [0.210, 0.668] P< 0.001 | 0.796 [0.430, 1.474] P=0.468 | 0.787 [0.403, 1.539] P=0.485 | 0.939 [0.450, 1.959] P=0.866 |
Induction Week 12 Clinical Outcomes as Predictors of Response at Maintenance Week 52 Odds Ratio [95% CI] P-value | SF/APS Clinical Response |
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| 1.538 [0.969, 2.442] P=0.068 | 1.418 [0.894, 2.249] P=0.137 | 1.596 [1.005, 2.535] P=0.048 | 2.880 [1.737, 4.774] P< 0.001 | 4.417 [2.466, 7.909] P< 0.001 | 3.517 [1.884, 6.565] P< 0.001 |
| SF/APS Clinical Remission |
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| 2.084 [1.095, 3.967] P=0.025 | 1.429 [0.760, 2.684] P=0.268 | 1.704 [0.889, 3.267] P=0.109 | 3.696 [1.904, 7.172] P< 0.001 | 5.368 [2.542, 11.337] P< 0.001 | 5.091 [2.264, 11.448] P< 0.001 |
| Endoscopic Response |
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| 1.066 [0.527, 2.156] P=0.860 | 0.886 [0.438, 1.793] P=0.736 | 1.279 [0.613, 2.666] P=0.512 | 3.592 [1.712, 7.540] P< 0.001 | 5.765 [2.663, 12.479] P< 0.001 | 6.314 [2.824, 14.120] P< 0.001 |
| Endoscopic Remission |
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| 1.186 [0.503, 2.796] P=0.696 | 0.810 [0.344, 1.907] P=0.629 | 1.067 [0.433, 2.625] P=0.888 | 4.342 [1.732, 10.887] P=0.002 | 9.227 [3.436, 24.776] P< 0.001 | 8.036 [2.934, 22.006] P< 0.001 |