A0382 - Predictors of Urgent Findings on CT in Crohn's Disease Patients

Firrah Saeed, MD¹, Hannah W. Fiske, MD², Joshua Ray Tanzer, PhD³, David Grand, MD³, Jonathan Movson, MD³, Samir A. Shah, MD, FACG^4
1Brown University/Rhode Island Hospital, New York, NY; ²Brown University/Rhode Island Hospital, Providence, RI; ³Brown University, Providence, RI; ⁴Warren Alpert Medical School / The Miriam Hospital, Providence, RI

Introduction: Crohn’s disease (CD) patients are exposed to substantial radiation from repeat CTs given multiple ED visits and early age of diagnosis, with concern that multiple scans infrequently identify clinically significant findings. Previous studies reported on predictors of urgent findings - obstruction, perforation, abscess, or non-CD urgent findings (OPAN) - on CT. We sought to identify patient characteristics correlating with increased number of scans and OPAN findings.

Methods: 660 CD patients from 4 gastroenterology practices presenting to one healthcare system with 3 hospitals from 4/15/15 to 12/31/18 were identified and cross-referenced with a radiology database search generating 1778 CT scans performed at these ED encounters. Presence of OPAN was noted. We manually chart reviewed a stratified random sample of 200 of these encounters, utilized cluster analysis to empirically group patients based on demographics and clinical profiles, and used generalized linear modeling to compare number of scans and meaningful clinical data between groups (Table 1).

Results: Patients presenting with acute and/or diffuse abdominal pain were more likely to undergo CT. Those with barriers to healthcare (including non-private insurance, missed outpatient appointments, infusion non-adherence, or limited English proficiency) had higher levels of ESR/CRP and increased rate of OPAN findings. Those with fewer barriers often had no/mild ESR/CRP elevations and lowest rate of OPAN findings. The group with the least biologic agent use and more missed appointments had the highest ESR/CRP and number of OPAN findings. A majority of patients with multiple ED visits and scans had anxiety/depression. The difference in rate of OPAN findings between each group was not statistically significant (Fig 1).

Discussion: Prior studies have shown that positive predictors of OPAN include high WBC, tachycardia, elevated inflammatory markers, and use of opioids and steroids which may mask pain. Negative predictors include biologic use and recent negative CT. Our study raises concerns about the barriers to healthcare with missed outpatient appointments, repeat scans, and inconsistent identification of presence of OPAN. Without proper adherence to outpatient follow-up, patients who develop abdominal pain or CD-related symptoms are more likely to present to the ED and be subsequently scanned. This data highlights the importance of improving social determinants of healthcare resources for CD to ultimately reduce excess radiation exposure.




Disclosures:


Firrah Saeed, MD¹, Hannah W. Fiske, MD², Joshua Ray Tanzer, PhD³, David Grand, MD³, Jonathan Movson, MD³, Samir A. Shah, MD, FACG⁴. A0382 - Predictors of Urgent Findings on CT in Crohn's Disease Patients, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.