E0642 - Rectal Evacuation Disorder Associated With a Higher Rate of Small Intestinal Bacterial Overgrowth Diagnosis Compared to Slow Transit Constipation

Wendy Zhou, DO¹, Leila Neshatian, MD, MSc², Houssam Halawi, MD^1
1Stanford University School of Medicine, Redwood City, CA; ²Stanford University School of Medicine, Stanford, CA

Introduction: Small intestinal bacterial overgrowth (SIBO) is being more and more recognized as a potential comorbidity in patients with constipation, likely causing additional symptoms, and posing as a challenge to the management of symptoms in this patient population. We aimed to compare the rate of SIBO in patients with Rectal Evacuation Disorder (RED) to that in patients with slow transit constipation (STC).

Methods: The electronic medical records of patients aged 18 or more were screened for the diagnoses of RED and STC between year 2015 and present at a tertiary care center in Northern California. We then screened the results for a diagnosis of SIBO based on a hydrogen breath test and an established SIBO diagnosis within one year. Chi-squared statistic was used to compare the rate of SIBO in patients with RED to that in patients with STC.

Results: 319 patients were identified with RED, of whom 256 (80.3%) were female. 954 patients were identified with STC, of whom 597 (62.6%) were female. The mean age (sd) was 57.7 (15.9) in RED and 58.7 (19.9) in STC. The rate of a SIBO diagnosis was significantly higher in patients with RED (7.84%) compared to patients with STC (1.78%) (p=0.000081).

Discussion: RED is associated with an increased rate of a SIBO diagnosis compared to slow transit constipation. Untreated RED may offer one explanation for the recurrent nature of SIBO in patients with constipation, and RED should thus be suspected and screened for in patients with constipation who are diagnosed with SIBO. Prospective research is needed to better understand the effect of RED on gut microbiome.


Disclosures:


Wendy Zhou, DO¹, Leila Neshatian, MD, MSc², Houssam Halawi, MD¹. E0642 - Rectal Evacuation Disorder Associated With a Higher Rate of Small Intestinal Bacterial Overgrowth Diagnosis Compared to Slow Transit Constipation, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.