D0689 - Gastroparesis Is Associated With More Psychiatric Disorders Than Functional Dyspepsia

Award: Presidential Poster Award

Gengqing Song, MD¹, Yuhan Fu, DO¹, Yan Sun, MD^2
1MetroHealth Medical Center/Case Western Reserve University, Cleveland, OH; ²Summa Health Medical Group, Stow, OH

Introduction: Gastroparesis (GP) and functional dyspepsia (FD) consist of a similar spectrum of upper gastrointestinal disorders differentiated by delayed gastric emptying in GP. Both GP and FD are associated with significant psychiatric disorders, including anxiety and depression. The goal of the study was to compare the prevalence of psychiatric disorders and prescription of psychotropic medications between GP and FD.

Methods: A cohort analysis was performed using IBM Explorys database (1999-2022), which contained de-identified healthcare information from over 300 hospitals across the United States. Explorys included information regarding medications, diagnosis, and procedures. We selected adult patients who have completed a gastric emptying study in the past and further divide them into GP and FD cohort groups. Cyclical vomiting syndrome, psychoactive substance abuse, eating disorder, factitious disorder, chemotherapy, malignant tumor of esophagus and stomach, neoplasm of abdomen, gastric or intestinal obstruction, IBD, adhesion of intestine, carcinomatosis, perforation of intestine, Roux-en-Y gastrojejunostomy, and gastrectomy were excluded. Exclusion criteria of FD are the same as gastroparesis cohort with additional exclusion criteria: gastroparesis, gastrointestinal ulcer, brain neoplasm and pancreatitis. Psychiatric disorder diagnosis and psychotropic medications were collected. The number of patients and respective percentages were obtained. Odds ratios (OR) with 95% confidence interval were used to compare the cohorts.

Results: We identified 17570 patients with GP and 60230 patients with FD (Table 1). There was a higher prevalence of psychiatric disorders in GP compared with FD, including anxiety (37.62% vs 27.56%), depression (42.17% vs 28.32%), bipolar disorders (6.55% vs 3.62%), posttraumatic stress disorders (PTSD, 3.81 % vs 2.01%) and schizophrenia (0.91% vs 0.48%) (all p value < 0.0001) (Figure 1). A significant proportion of patients with GP and FD were on selective serotonin reuptake inhibitors (SSRI, 47.58% vs 34.19%) and benzodiazepines (BZ, 68.13 vs 55.24%). Psychotropic medications were more commonly prescribed for patients with GP than FD, including tricyclic antidepressants, SSRI, serotonin–norepinephrine reuptake inhibitor, Mirtazapine, Buspirone, antipsychotic agents and BZ (combined OR range 1.65-2.41, p< 0.0001).

Discussion: GP is associated with more psychiatric disorders than FD. Psychotropic medications are more commonly prescribed for patients with GP compared with FD.




Disclosures:


Gengqing Song, MD¹, Yuhan Fu, DO¹, Yan Sun, MD². D0689 - Gastroparesis Is Associated With More Psychiatric Disorders Than Functional Dyspepsia, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.