C0683 - Factors Associated With Delayed Gastric Motility: A Retrospective Case-Control Study

Akram I. Ahmad, MBBS¹, Claire Caplan, MD, MS², Ahmad Al-Dwairy, MD³, Arielle Lee, BS⁴, Brittney Rodriguez, MD⁵, Tarek W. Bakain, MBBS⁶, Loveleen Bhogal, MD¹, Naveera Khan, MBBS¹, Danial Nadeem, MD⁷, Sixian Wang, BA⁴, Ankit Mishra, MS⁴, Brian Benenati, BS, MBS⁸, Alex E. Akman, MS⁴, Lynette Sequeira, BS⁹, Shalin Zhang, BS¹⁰, Samantha Marshall, BA¹¹, Corinne O’Connor, BA¹¹, Daniel Childers, BS⁴, Won k. Cho, MD^12
1Medstar Washington Hospital Center, Washington, DC; ²University of Colorado Anschutz, Aurora, CO; ³Medstar Georgetown -Washington Hospital Center, Washington, DC; ⁴Georgetown University School of Medicine, Washington, DC; ⁵Memorial Healthcare System, Pembroke Pines, FL; ⁶MedStar Washington Hospital Center, Washington, DC; ⁷MedStar Washington Hospital Center, Danville, PA; ⁸Georgetown University School of Medicine, Demarest, NJ; ⁹Georgetown University, Richmond, VA; ¹⁰Georgetown University, Washington, DC; ¹¹Georgetown University School of Medicine, Arlington, VA; ¹²Inova Fairfax Hospital, Washington, DC

Introduction: Gastrointestinal motility is regulated by peristalsis and segmentation. Peristaltic regulation is mainly by hormones and the autonomic nervous system. The current literature does not provide data on different pathological diseases that may affect motility. We aim to do a retrospective study to correlate different factors that may delay gastric motility.

Methods: A retrospective review of the Nuclear Medicine procedure database was performed for all patients having Gastric Emptying Study (GES) between 2011 and 2020. The research protocol was approved by the Institutional Board Review of the MedStar Washington Hospital Center. Patients included if GES was performed and have laboratory data available within six weeks of the index study. Exclusion criteria were duplicate studies, failure to complete gastric emptying study, patients on medications known to affect gastric function, and previous gastric surgery. The p-values are for comparison of demographic and laboratory characteristics between the study groups. We used the chi-squared test for categorical variables and the T-test for continuous variables.

Results: 1205 GES was done between 2011 and 2020. Of those studies, 455 fit our inclusion criteria. 73 patients had delayed gastric emptying, while 334 patients had normal gastric emptying studies. The mean age for the delayed group was 51.7 years old, without a significant difference from normal gastric emptying (p= 0.268).

Female represent 47 patients (64.4%), while male represent 26 patient's (35.6%) in the delayed emptying group, with no significant difference between the study group (P = 0.26). The delayed emptying group has a higher rate of chronic kidney disease at 17.8% (P = 0.004) and diabetes at 54.8% (P= 0.001) in comparison with 7.5% and 24.9% consecutively. Other comorbidities such as infections around the time of the study, cirrhosis, and hypothyroidism, did not reach statistical significance. On laboratory values, magnesium and glucose were significantly higher in the delayed emptying group (P < 0.001). Other laboratory findings as T4, hemoglobin A1c, phosphorus, albumin, and creatinine level were not significant.

Discussion: We found in our study that diabetic patients and Chronic kidney disease have a higher tendency to delayed gastric emptying. Magnesium and glucose had the same effect on gastric emptying. Further studies are needed to validate these findings.



Disclosures:


Akram I. Ahmad, MBBS¹, Claire Caplan, MD, MS², Ahmad Al-Dwairy, MD³, Arielle Lee, BS⁴, Brittney Rodriguez, MD⁵, Tarek W. Bakain, MBBS⁶, Loveleen Bhogal, MD¹, Naveera Khan, MBBS¹, Danial Nadeem, MD⁷, Sixian Wang, BA⁴, Ankit Mishra, MS⁴, Brian Benenati, BS, MBS⁸, Alex E. Akman, MS⁴, Lynette Sequeira, BS⁹, Shalin Zhang, BS¹⁰, Samantha Marshall, BA¹¹, Corinne O’Connor, BA¹¹, Daniel Childers, BS⁴, Won k. Cho, MD¹². C0683 - Factors Associated With Delayed Gastric Motility: A Retrospective Case-Control Study, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.