C0392 - Utility of Intestinal Ultrasound (IUS) and Its Comparison to Other Diagnostic Modalities in Patients With Crohn's Disease: A Systematic Review and Meta-Analysis
Corrine Kickel, DO1, Julia Liberto, 2, Brian Quigley, PhD3, Muhammad Tahir, MD3 1University at Buffalo, Kenmore, NY; 2Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY; 3University at Buffalo, Buffalo, NY
Introduction: Intestinal Ultrasound (IUS) is a relatively new modality being used for diagnostic purposes in the inflammatory bowel disease world. In the latest studies, IUS has performed comparable to other modalities and also correlates with biochemical disease markers. In our study, we planned to compare the results of this modality compared to other modes.
Methods: 17 articles were included for review. A search was completed through PubMed, Oxford Academic and American Gastroenterology journal.Comparison of sensitivity, specificity, and accuracy was done between IUS and other procedures in the studies identified.Total sample of all studies N =964 (46% Female). Mean age of all studies M=38.80. We calculated weighted average of certain variables during the analysis.
Results: In nine studies, IUS had a mean Sensitivity of .90 (SD = 0.15) while other procedures demonstrated a mean Sensitivity of .77 (SD = 0.15),in a one sided test this was a significant difference, t(8) = 1.92, p = .045,which corresponded with an effect size of d = 0.64 (95% CI = -0.09 / 1.34). In eight studies examining both Specificity in IUS and other procedures, IUS had a mean Sensitivity of .78 (SD = 0.14) while other procedures demonstrated a mean Specificity of .82 (SD = 0.22), with a non-significant difference, t(7) = -0.52, p = .308, d = -0.18 (95% CI = -0.88 / 0.52). Three studies compared ICU and other procedures in accuracy. IUS had a mean Accuracy of .75 (SD = 0.04) while other procedures demonstrated a mean Specificity of .72 (SD = 0.14), which was a non-significant difference, t(2) = 0.29, p = .400, d = 0.17 (95% CI = -0.99 / 1.29). Procedural factors which may affect Sensitivity, Specificity, and Accuracy in the IUS procedure were examined if there were at least 3 studies available to make a comparison. Stricture Stenosis, abscess, dilation, fistula formation was associated with greater Sensitivity & Specificity in IUS while MRE was assumed with greater Sensitivity and Specificity when not present. Effect sizes calculated should be taken with caution due to the small number of studies and the large 95% confidence intervals associated with each effect.
Discussion: IUS evaluation of CD flare offers an alternative noninvasive modality that is comparable while limiting radiation exposure. This allows providers the ability to monitor for resolution of pathology at bedside as well and status changes during follow up visits. A limitation of this study is the lack of information however it provides a continued area of research.
Figure: Figure 1: Sensitivity, Specificity, and Accuracy of SICU compared to Other Imaging Modalities including CT, MRE, and transabdominal US
Disclosures:
Corrine Kickel indicated no relevant financial relationships.
Julia Liberto indicated no relevant financial relationships.
Brian Quigley indicated no relevant financial relationships.
Muhammad Tahir indicated no relevant financial relationships.
Corrine Kickel, DO1, Julia Liberto, 2, Brian Quigley, PhD3, Muhammad Tahir, MD3. C0392 - Utility of Intestinal Ultrasound (IUS) and Its Comparison to Other Diagnostic Modalities in Patients With Crohn's Disease: A Systematic Review and Meta-Analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.
