D0092 - Idiopathic Myointimal Hyperplasia of Mesenteric Veins: A Systematic Review and Individual Patient Regression Analysis

Raquel Rozner, MD¹, Savanah D. Gisriel, MD, MPH², John Damianos, MD¹, Alyssa A. Grimshaw, MS, MBA³, Rabia Rizwan, MD¹, Ahmad Nawaz, MD¹, Kevin Chan, MD⁴, David Wan, MD⁵, Haddon Pantel, MD¹, Abdul Qadir Bhutta, MD⁶, Marc Fenster, MD⁷, Lawrence Brandt, MD, MACG⁷, Andrea Barbieri, MD¹, Marie Robert, MD¹, Paul Feuerstadt, MD, FACG⁸, Darrick K. Li, MD, PhD^1
1Yale University School of Medicine, New Haven, CT; ²Yale-New Haven Hospital, New Haven, CT; ³Yale Cushing/Whitney Medical LIbrary, New Haven, CT; ⁴Weill Cornell Medical College, New York, NY; ⁵New York-Presbyterian Hospital/Weill Cornell Medicine, New York, NY; ⁶SUNY Upstate Syracuse University Hospital, Syracuse, NY; ⁷Montefiore Medical Center, Bronx, NY; ⁸PACT Gastroenterology Center and Yale University School of Medicine, New Haven, CT

Introduction: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is an uncommon cause of colonic ischemia for which surgical treatment is recommended. We describe the clinical, radiologic and endoscopic findings in IMHMV patients to provide clinicians with a framework for the identification of this rare disease.

Methods: We performed a systematic review of seven databases for cases of IMHMV and identified additional cases from Yale New Haven Hospital records. To identify features specifically associated with colonic ischemia due to IMHMV, we performed multivariate logistic regression analysis incorporating data from a large, well-characterized multicenter cohort of biopsy-proven ischemic colitis (n=923).

Results: A total of 123 patients with IMHMV were identified from 58 publications and 3 unpublished cases at Yale New Haven Hospital (80% male, mean age 53, 56% Caucasian). Symptoms at presentation were most commonly abdominal pain (87%) and diarrhea (67%). The most affected areas were the sigmoid colon (89%) and rectum (66%). Median time from symptom onset to diagnosis was 4 months. Complications, including obstruction and perforation due to diagnostic delay occurred in 33% of patients. The most common radiologic feature was thickening of the affected segment of colon (97%). Anatomic vascular abnormalities including non-opacification of the inferior mesenteric vein were observed in 38% of patients. 97% of patients ultimately underwent curative segmental colectomy. Mean follow-up time was 23.6 months. Compared to biopsy-proven non-IMHMV colonic ischemia, IMHMV was significantly associated with younger age (p=0.010), male sex (p=0.002), rectal involvement on imaging (p=0.027) and on endoscopic evaluation (p=0.004), mucosal ulcerations on endoscopy (p=0.049) and absence of rectal bleeding on presentation (p< 0.001) (Table 1).

Discussion: IMHMV is a rare, underreported cause of colonic ischemia that predominantly involves the left colon. Using the largest IMHMV cohort to date and comparing to a multicenter cohort of patients with ischemic colitis, we identify clinical, endoscopic, and radiologic characteristics of this entity. Our findings suggest younger age, rectal involvement, and absence of rectal bleeding as clinical features to help identify select patients presenting with colonic ischemia as having higher likelihood of IMHMV and therefore consideration of upfront surgical management.



Disclosures:


Raquel Rozner, MD¹, Savanah D. Gisriel, MD, MPH², John Damianos, MD¹, Alyssa A. Grimshaw, MS, MBA³, Rabia Rizwan, MD¹, Ahmad Nawaz, MD¹, Kevin Chan, MD⁴, David Wan, MD⁵, Haddon Pantel, MD¹, Abdul Qadir Bhutta, MD⁶, Marc Fenster, MD⁷, Lawrence Brandt, MD, MACG⁷, Andrea Barbieri, MD¹, Marie Robert, MD¹, Paul Feuerstadt, MD, FACG⁸, Darrick K. Li, MD, PhD¹. D0092 - Idiopathic Myointimal Hyperplasia of Mesenteric Veins: A Systematic Review and Individual Patient Regression Analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.