C0024 - Prevalence of Depression in Patients With Chronic Pancreatitis: A Systematic Review and Meta-Analysis

Renato Beas, MD¹, Ahmad Karkash, MD¹, Diego Chambergo-Michilot, BS², Rawan Aljaras, MD¹, Eleazar E. Montalvan-Sanchez, MD¹, Celeste Díaz-Pardavé, MD², Adrian Riva-Moscoso, BS³, Mirian Ramirez-Rojas, MLIS⁴, Gerardo Calderon, MD^4
1Indiana University School of Medicine, Indianapolis, IN; ²Universidad Científica del Sur, Lima, Perú, Indianapolis, IN; ³Escuela de Medicina, Universidad Peruana de Ciencias Aplicadas, Indianapolis, IN; ⁴Indiana University, Indianapolis, IN

Introduction: Chronic Pancreatitis (CP) is a fibroinflammatory condition with debilitating symptoms affecting 35-50% of individuals worldwide. Quality of life is severely affected in patient with CP and they are likely to suffer from mental health disorders, including depression. We conducted a systematic review and meta-analysis assessing the prevalence of Depression in patients with CP.

Methods: Multiple electronic databases including PubMed, MEDLINE (OVID), PsycINFO, Cochrane Library, Embase, Scopus and Web of Science were searched from inception to June 2022 to identify manuscripts reporting the prevalence of Depression (diagnosed clinically or with a validated scale without language restriction) among patients with Chronic Pancreatitis of any etiology. Case series, reports, editorials, and reviews were excluded. Two independent reviewers extracted data. Disagreements were resolved by a third author. The pooled prevalence was calculated using a random effects model. Heterogeneity was assessed by the inconsistency index (I2).

Results: Among 3647 articles identified, 58 studies were identified for full text review, and ultimately nine studies were deemed eligible for inclusion with perfect agreement (kappa=1.0). Five of them were cross-sectional studies, whereas the rest were cohorts. A total of 87136 patients were included in the studies (Table 1). CP was determined with previous historical diagnosis, the M-ANNHEIM criteria and the presence of a clinical, radiologic and/or endosonographic features. Depression was diagnosed clinically and using Center for Epidemiological Studies 10-item Depression Scale (CESD), Beck Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS). Depression prevalence in patients with CP varied from 11%-70% among the studies. The pooled prevalence of Depression in CP patients was 39% (95% CI 0.26-0.53) (Figure 1). Four studies included healthy controls with lower prevalences of Depression.

Discussion: Depression among patients with CP deserves a call-to-action due to its medical implications and worsening quality of life. Chronic pain and malabsorption symptoms could predispose to the development of Depression. Our findings raise awareness of the importance of screening patients with chronic pancreatitis for mental health disorders and provide support. Further well-designed clinical trials would be necessary to test tentative therapeutic measures seeking the reduction of symptoms for this specific group of patients.




Disclosures:


Renato Beas, MD¹, Ahmad Karkash, MD¹, Diego Chambergo-Michilot, BS², Rawan Aljaras, MD¹, Eleazar E. Montalvan-Sanchez, MD¹, Celeste Díaz-Pardavé, MD², Adrian Riva-Moscoso, BS³, Mirian Ramirez-Rojas, MLIS⁴, Gerardo Calderon, MD⁴. C0024 - Prevalence of Depression in Patients With Chronic Pancreatitis: A Systematic Review and Meta-Analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.