A0010 - Epidemiology and Outcomes of Sarcopenia in Patients With Chronic Pancreatitis: A Nationwide Population-Based Study

Sunday, October 23, 2022

5:00 PM – 7:00 PM ET

Location: Crown Ballroom

Has Audio

Presenting Author(s)

Khaled Alsabbagh Alchirazi, MD

Cleveland Clinic
Cleveland, OH

Khaled Alsabbagh Alchirazi, MD¹, Abdul Mohammed, MD¹, Ashraf Almomani, MD², Almaza A. Albakri, MD³, Mariam Naveed, MD⁴
¹Cleveland Clinic, Cleveland, OH; ²Cleveland Clinic Foundation, Cleveland, OH; ³Royal Jordanian Medical Services, Amman, Al Karak, Jordan; ⁴AdventHealth, Altamonte Springs, FL

Introduction: Patients with chronic pancreatitis (CP) frequently have more advanced malnutrition. Various factors such as pain, alcoholism, malabsorption, and maldigestion from pancreatic exocrine insufficiency render these patients at increased risk for sarcopenia. This work intends to assess the prevalence of sarcopenia in CP and its outcomes.

Methods: We reviewed data from a large multi-center database (Explorys IBM) aggregated from 26 large nationwide healthcare systems. Using systemized nomenclature of clinical medical terms (SNOMED CT), CP patients with and without sarcopenia were identified. Additionally, demographic data, including age, sex, race, ethnicity, smoking habits, and outcomes of CP, were obtained. We calculated the odds ratio (OR) using a univariate analysis model.

Results: Among 69 million adult patients in the database, 106,540 patients with CP were identified, and 31.3% of these patients were found to have sarcopenia. Patients with history of sarcopenia were more likely to be elderly ( >65-years-old) (OR: 1.26; 95% confidence interval [CI] 1.23-1.29; P < 0.0001), female (OR, 1.11; 95% CI, 1.08–1.13; P < 0.0001), Caucasian (OR, 1.09; 95% CI, 1.06–1.11; P < 0.0001), and smokers (OR 1.53; 95% CI 1.49-1.57, P < 0.0001). CP patients with sarcopenia had increased prevalence of primary pancreatic malignancy (OR, 1.47; 95% CI, 1.4–1.55; P < 0.0001), pancreatic pseudocyst (OR, 1.41; 95% CI, 1.36–1.47; P < 0.0001), exocrine pancreatic insufficiency (OR, 1.93; 95% CI, 1.4–2.65; P = 0.0001), pancreatic malabsorption (OR, 1.72; 95 CI, 1.51-1.97; P < 0.0001), venous thrombosis (OR, 1.57; 95% CI, 1.53–1.62; P < 0.0001), and gastrointestinal hemorrhage (OR, 2.69; 95% CI, 2.63–2.75; P < 0.0001) (Table 1).

Discussion: This is the largest study to characterize the epidemiology and outcomes of chronic pancreatitis patients with sarcopenia. Our data indicate that sarcopenia is associated with an increased risk of CP complications and may be an important prognostic factor in CP.

	CP with sarcopenia (n=48,220)	CP without sarcopenia (n=106,050)	OR (CI)	P-value
Demographics
>65	21,970 (46%)	42,250 (40%)	1.26 (1.23-1.29)	< 0.0001
Female	24,410 (51%)	50,970 (48%)	1.11 (1.08-1.13)	< 0.0001
Caucasian	33,810 (70%)	72,500 (68%)	1.09 (1.06-1.11)	< 0.0001
Smoking	31,120 (77%)	72,700 (69%)	1.53 (1.49-1.57)	< 0.0001
CP outcomes
Exocrine pancreatic insufficiency	70 (0.2%)	80 (0.1%)	1.93 (1.4-2.65)	0.0001
Pancreatic malabsorption	390 (1%)	500 (0.5%)	1.72 (1.51-1.97)	< 0.0001
Pancreatic Pseudocyst	4,640 (10%)	7,440 (7%)	1.41 (1.36 -1.47)	< 0.0001
Primary pancreatic malignancy	2,400 (5%)	3,640 (3%)	1.47 (1.4-1.55)	< 0.0001
Gastrointestinal hemorrhage	15,540 (32%)	24,050 (23%)	2.69 (2.63-2.75)	< 0.0001
Venous thrombosis	10,350 (22%)	15,690 (15%)	1.57 (1.53-1.62)	< 0.0001

Table: Table 1. Comparison of baseline characteristics and outcomes of CP with and without sarcopenia.

Disclosures:

Khaled Alsabbagh Alchirazi indicated no relevant financial relationships.

Abdul Mohammed indicated no relevant financial relationships.

Ashraf Almomani indicated no relevant financial relationships.

Almaza Albakri indicated no relevant financial relationships.

Mariam Naveed indicated no relevant financial relationships.

Khaled Alsabbagh Alchirazi, MD¹, Abdul Mohammed, MD¹, Ashraf Almomani, MD², Almaza A. Albakri, MD³, Mariam Naveed, MD⁴. A0010 - Epidemiology and Outcomes of Sarcopenia in Patients With Chronic Pancreatitis: A Nationwide Population-Based Study, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.