A0249 - Nutritional Aspects in Patients With Gastroparesis: Normal BMI Despite Abnormal Intake!

Rawan Aljaras, MD¹, Noor Abu-Farsakh, MD², Renato Beas, MD³, Eleazar E. Montalvan-Sanchez, MD¹, Maryam Haidar, MD⁴, Ahmad Karkash, MD³, Mirian Ramirez-Rojas, MLIS³, Gerardo Calderon, MD^3
1Indiana University School of Medicine, Indianapolis, IN; ²Jordan University Hospital, Amman, 'Amman, Jordan; ³Indiana University, Indianapolis, IN; ⁴Detroit Medical Center - Sinai Grace, Indianapolis, IN

Introduction: Patients with gastroparesis have signs and symptoms including nausea, vomiting, and early satiety, thus leading to inadequate food intake and a high risk of malnutrition. The classic clinical picture of gastroparesis is a symptomatic patient losing weight. We performed a systematic review and a meta-analysis to identify average body mass index (BMI) in patients with gastroparesis.

Methods: Medline, Embase, Cochrane, CINAHL, and Scopus were searched for longitudinal studies reporting on nutrition in adult patients with gastroparesis. A search strategy was developed with core terms including “gastroparesis”, “BMI”, “calorie”, and “nutrition”. The main outcome was determined to be the average BMI in patients with gastroparesis. The secondary outcome was average calorie intake in these patients. Data was pooled and I^2 values were calculated to determine heterogeneity. No controls were identified for analysis.

Results: Initial database search resulted in 3999 studies (n=3999). 16 relevant studies were identified for full text review (n=16). 5 studies were identified eligible to be included in the average BMI meta-analysis after applying inclusion and exclusion criteria (n=5). The weighted average BMI in patients with gastroparesis was calculated at (26.1 kg/m^2). Heterogeneity (I^2 value) for these studies was noted to be moderate at 46.7% (Figure 1A). 3 of the initial 16 studies identified for full review reported on distribution of patients with gastroparesis among different BMI categories with details shown in table (Figure 1B). Another 3 studies were identified eligible to be included in the average calorie intake meta-analysis (n=3). Weighted average calorie intake in patients with gastroparesis was calculated at (1161 kcal/day), forest plot is shown in (Figure 2).

Discussion: Weighted average BMI in patients with gastroparesis laid in the overweight category, with most patients noted of normal weight per distribution of patient’s prevalence per category of BMI (Figure 1B). These results contradict with what is commonly thought of these patients being likely underweight for their inability to meet dietary requirements. Average calorie intake in patients with gastroparesis is found to be less than the recommended daily intake for adult males and females in the US. Reasons why patients are mostly of normal weight to overweight despite less than recommended daily calorie intake are not well understood and more investigations of other factors affecting BMI in these patients is warranted.



Disclosures:


Rawan Aljaras, MD¹, Noor Abu-Farsakh, MD², Renato Beas, MD³, Eleazar E. Montalvan-Sanchez, MD¹, Maryam Haidar, MD⁴, Ahmad Karkash, MD³, Mirian Ramirez-Rojas, MLIS³, Gerardo Calderon, MD³. A0249 - Nutritional Aspects in Patients With Gastroparesis: Normal BMI Despite Abnormal Intake!, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.