B0401 - Cannabidiol (CBD) Use in Inflammatory Bowel Disease

Karina Fatakhova, MD¹, Sapphire Perera, ², Royce Perera, ², Benjamin Glazebnik, ², Pratik Patel, MD³, Emily Glazer, MD⁴, Greg Haggerty, PhD⁵, Ramona Rajapakse, MD^4
1Northwell Health at Mather Hospital, Port Jefferson, NY; ²Zucker School of Medicine at Hofstra/Northwell Health, Port Jefferson, NY; ³Northwell Health at Mather Hospital, Middle Island, NY; ⁴Mather Hospital, Port Jefferson, NY; ⁵Northwell Health, Port Jefferson, NY

Introduction: Cannabidiol (CBD) is a cannabinoid compound found in cannabis that has been gaining attention over the past few years in the medical community. Unlike tetrahydrocannabinol, also found in cannabis, it does not have psychoactive effects. It is easily obtainable, mixed in an oil or gummy form, and available in different strengths and flavors. CBD is used for pain, anxiety, depression and insomnia. While marijuana use has been widely studied in patients with Inflammatory Bowel Disease (IBD), there are few studies on the use and effects of CBD in this population. The purpose of this survey based study is to determine the number of IBD patients using CBD products, why they use them and if they perceive any benefits.

Methods: 229 patients over the age of 18 with a diagnosis of IBD, from two gastroenterology outpatient clinics in Suffolk county, NY were invited to participate in an anonymous survey from June 1st to June 16th, 2022. The survey consisted of 13 questions pertaining to demographics, IBD related history, cancer history and CBD use. The surveys were completed in the office or by telephone. Data was entered into an anonymous database for interpretation.

Results: Of the 229 patients, 10.5% used CBD products (n=24). Of the CBD users, more than half (66.7%, n=11) were female, 14 had Crohn’s disease while the rest had Ulcerative colitis, 37.5% (n=9) were on biologic therapy, and 9 (37.5%) had an IBD related surgery. Anxiety (62.5%, n=15), insomnia (54.2%, n=13) and pain (41.7%, n=10) were the most commonly reported reasons for use of CBD. Increase in appetite (25%, n=6) and nausea and vomiting (20.8%, n=5) were also reasons for use but were not reported as frequently. The majority of patients (87.5 %, n=21) felt that CBD helped their symptoms.

Discussion: IBD patients frequently suffer from pain, anxiety, insomnia and depression. There has been a rise in the use of CBD products in patients with various medical conditions. In our small study, we found that only 10.5% of IBD patients use CBD products, mainly for anxiety, insomnia and pain, compared with arthritis where reported use is 50% or more. Patients with IBD who have a complicated disease process often seek alternative therapies and are therefore at risk for substance use. Until there are large clinical trials to assess the role and safety profile of CBD in IBD patients, clinicians should be aware of its use in this population.



Disclosures:


Karina Fatakhova, MD¹, Sapphire Perera, ², Royce Perera, ², Benjamin Glazebnik, ², Pratik Patel, MD³, Emily Glazer, MD⁴, Greg Haggerty, PhD⁵, Ramona Rajapakse, MD⁴. B0401 - Cannabidiol (CBD) Use in Inflammatory Bowel Disease, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.