B0492 - Prevalence and Epidemiological Characteristics of Non Alcoholic Fatty Liver Disease in the U.S. Population

Ammu Thampi Susheela, MD¹, Tushar Khanna, MD², Arpankumar Patel, MBBS³, Vrushali Shelar, MBBS⁴, Apurva Popat, MD⁵, Priyanka Gupta, MBBS⁶, Yash Deshpande, MBBS⁷, Antara Chatterjee, MBBS⁸, Cyril Hernandez, MD⁹, Mandeep Kaur, MD¹⁰, Laseena Vaisyambath, MD¹¹, Sindhura Allala, MD¹², Samana Mustafa, MBBS¹³, Sameer Dawoodi, MD¹⁴, Raja Chandra Chakinala, MD¹⁵, Pratikkumar Vekaria, MD¹⁶, Urvish K. Patel, MD, MPH^17
1Loyola Medical Center, Maywood, IL; ²St. Mary Mercy Hospital, Livonia, MI; ³G.M.E.R.S. Medical College, Ahmedabad, Gujarat, India; ⁴Saratov State Medical University, Saratov, Saratov, Russia; ⁵Larkin Comunity Hospital, Miami, FL; ⁶University of Illinois at Chicago College of Medicine, Chicago, IL; ⁷Grant Government Medical College and J.J Group of Hospitals, Mumbai, Maharashtra, India; ⁸Breach Candy Hospital, Mumbai, Maharashtra, India; ⁹Our Lady of Fatima College of Medicine, Valenzuela City, Bataan, Philippines; ¹⁰Government Medical College, Patiala, Punjab, India; ¹¹Markham Stouffville Hospital, Markham, Markham, ON, Canada; ¹²Windsor University School of Medicine, Cayon, Saint George Basseterre, Saint Kitts and Nevis; ¹³Alvarado Hospital Medical Center, San Diego, CA; ¹⁴Yale New Haven Health, New Haven, CT; ¹⁵Guthrie Robert Packer Hospital, Philadelphia, PA; ¹⁶Prisma Health Upstate, Greenville, SC; ¹⁷Icahn School Medicine at Mount Sinai, New York, NY

Introduction: Non-alcoholic fatty liver disease is a biologically and clinically heterogeneous multisystem disorder that affects one-quarter of the global adult population and causes substantial social and economic implications. They may present as isolated hepatic steatosis, non-alcoholic steatohepatitis, hepatic fibrosis, cirrhosis, liver cancer, end-stage liver disease, and death. There is limited literature describing the national prevalence and epidemiological characteristics of NAFLD in the US population. The primary outcome of the study was to evaluate the concurrent prevalence and lifestyle diseases among NAFLD.

Methods: A retrospective cross-sectional study using the NHANES database from 2015-to 2018 was conducted. The datasets were downloaded from the NHANES web site and combined using SAS software (Version 9.4). Proper weighting procedures for weighting multiple years of NHANES data were employed for this study. We included participants that aged ≥18 years and had completed data from the NHANES questionnaires. Univariate and multivariate logistic regression analysis was conducted to evaluate the prevalence and epidemiology of NAFLD and the association of NAFLD with lifestyle disorders

Results: Of the total 255,968 sample size, the total number of people identified with NAFLD was 717 (0.26%). NAFLD was more prevalent in older (median: 62 years), males, Mexican American and other Hispanics, and in those with median household income >$100,000. People with NAFLD had a higher prevalence odds of having Diabetes Mellitus (OR: 10.40, 95% CI: 10.37-10.42 p < 0.001), cancer

(OR: 2. 10, 955 CI: 2.09-2.10, p < 0.001), depression (OR: 2.528, 95% CI: 2.52-2.53 p < 0.001), hypersomnia (OR: 1.36, 95% CI: 1.34-1.36 p < 0.001), obesity (OR: 1.08, 95% CI: 1.08-1.08, p < 0.001), low dietary fibre intake (OR: 1.18, 95% CI: 1.18-1.19), a sedentary lifestyle (OR: 1.47, 95% CI: 1.46-1.472, p < 0.001)

Discussion: People with NAFLD had a higher association of having lifestyle disorders including diabetes, obesity, depression, hypersomnia, low dietary fibre intake, and a sedentary lifestyle. Cancer was also found to be higher among people with NAFLD. Our study summarises the epidemiological characteristics of NAFLD in the US population. Early identification and risk mitigation strategies with active lifestyle might reduce the burden of NAFLD associated disorders.


Disclosures:


Ammu Thampi Susheela, MD¹, Tushar Khanna, MD², Arpankumar Patel, MBBS³, Vrushali Shelar, MBBS⁴, Apurva Popat, MD⁵, Priyanka Gupta, MBBS⁶, Yash Deshpande, MBBS⁷, Antara Chatterjee, MBBS⁸, Cyril Hernandez, MD⁹, Mandeep Kaur, MD¹⁰, Laseena Vaisyambath, MD¹¹, Sindhura Allala, MD¹², Samana Mustafa, MBBS¹³, Sameer Dawoodi, MD¹⁴, Raja Chandra Chakinala, MD¹⁵, Pratikkumar Vekaria, MD¹⁶, Urvish K. Patel, MD, MPH¹⁷. B0492 - Prevalence and Epidemiological Characteristics of Non Alcoholic Fatty Liver Disease in the U.S. Population, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.