A0287 - Epidemiological Disparities in Trends of Gastrointestinal Hemorrhage-Related Hospitalizations and In-Hospital Mortality in Young Females of Reproductive Age: A National Inpatient Perspective

Yashwitha Sai Pulakurthi, MBBS¹, Praneeth Reddy Keesari, MBBS², Swathi Veliginti, MBBS³, Harikrishnan Sukhesh, MBBS⁴, Ayodya Perera, MD⁵, Anjani K. Thota, MBBS⁶, Vamshi Reddy Matli, ⁷, Gokul Paidi, MBBS⁸, Jayasree Ravilla, MD⁹, Mani Chandan Reddy Patlolla, MBBS¹⁰, Rupak Desai, MBBS^11
1New York Medical College- Saint Michael's Medical Center, Newark, NJ; ²Staten Island University Hospital, Staten Island, NY; ³ADRM Hospital, Hyderabad, Telangana, India; ⁴Government Medical College Kottayam, Kottayam, Kerala, India; ⁵Tbilisi State Medical University, Tbilisi, T'bilisi, Georgia; ⁶NTR University of Helath and Sciences, Hyderabad, Telangana, India; ⁷Kamineni Academy of Medical Sciences and Research Centre, Tirupati, Andhra Pradesh, India; ⁸Arizona Lung Sleep and Valley Fever Institute, Phoenix, AZ; ⁹Monmouth Medical Center, Long Branch, NJ; ¹⁰Kamineni Institute of Medical Sciences, Hyderabad, Telangana, India; ¹¹Independent Researcher, Atlanta, GA

Introduction: Epidemiology and outcomes pertaining to gastrointestinal hemorrhage (GIH) in young females remain under studied. We aimed to study the prevalence, odds and in-hospital mortality of GIH related hospitalizations with associated racial, socioeconomic and regional disparities in young females of reproductive age (YFRA, 18-44 years).

Methods: Data was obtained from National inpatient sample 2019 using relevant ICD-10 codes. We identified YFRA hospitalizations and categorized them into GIH and without GIH. Demographic data, comorbidities, Primary outcomes (prevalence of GIH, in-hospital mortality) were compared between groups stratified by race, socioeconomic status and geographic regions. Secondary outcomeswere length of stay and cost. Multivariate regression analyses were performed adjusting for sociodemographics, hospital characteristics and comorbidities.

Results: Of total 6071529 admissions in YFRA, 48640 (0.8%) had GIH (median age 35, IQR 29-40). Stratified by race, Asian pacific islanders (API, 22.3%) followed by Hispanics (18.9%) had higher rates of GIH (p< 0.001). YFRA from Lowest median income quartile (14.5%) demonstrated higher rates of GIH. Geographically, Western region hospitals showed highest (15.5%) rate of GIH admissions followed by Southern (14.3%), midwest (13.2%) and northeast (12.7%) (fig 1). Rates of alcohol abuse, drug abuse, depression, diabetes, hypertension, hyperlipidemia were higher in the GIH cohort. When adjusted for confounders, the odds of GIH by race were higher in API vs. white (aOR 1.76;1.45-2.12) (p< 0.001) and by region, hospitals from West region demonstrated the highest odds vs. Northeastern region (aOR 1.20;1.10-1.31)(p< 0.001). In-hospital mortality in GIH admissions was comparablebetween all regions without statistically significant difference. Median length of stay for GIH hospitalizations was 3 days (IQR 2-6) and total charges were higher compared to non GIH cohort ($37576 vs $20613, p< 0.001).

Discussion: GIH related hospitalizations among YFRA were highest in the West whereas subsequent inhospital mortality was highest in the Northeast region. API demonstrated the highest rates of GIH hospitalizations and in-hospital mortality. GIH admissions in YFRA from two lowermost income quartiles demonstrated the highest rate of GIH hospitalizations and subsequent mortality, respectively. Future studies are warranted to confirm these prevailing sex and regional disparities in GIH among YFRA.



Disclosures:


Yashwitha Sai Pulakurthi, MBBS¹, Praneeth Reddy Keesari, MBBS², Swathi Veliginti, MBBS³, Harikrishnan Sukhesh, MBBS⁴, Ayodya Perera, MD⁵, Anjani K. Thota, MBBS⁶, Vamshi Reddy Matli, ⁷, Gokul Paidi, MBBS⁸, Jayasree Ravilla, MD⁹, Mani Chandan Reddy Patlolla, MBBS¹⁰, Rupak Desai, MBBS¹¹. A0287 - Epidemiological Disparities in Trends of Gastrointestinal Hemorrhage-Related Hospitalizations and In-Hospital Mortality in Young Females of Reproductive Age: A National Inpatient Perspective, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.