B0392 - Association of Irritable Bowel Syndrome and Antibodies Against Endogenous Gonadotropin-releasing Hormone and Its Receptor. a Systematic Review and Meta-analysis

Karam R.Motawea, ¹, Joseph Varney, MD², Mohamed Gamal, MBBCh³, Kirellos Said Abbas, MBBCh¹, Fatma Monib, MBBCh⁴, Sarya Swed, MBChB⁵, Sara Gebril, MBBCh⁶, Mohamed Kishk, MBBCh⁷, Hazem Dahshan, MBBCh⁷, Ibrahim Rakha, MBBCh⁷, Tharun Reddi, MBBCh⁸, Noheir Hassan, MD⁹, Aryan Arora, MD¹⁰, Mohamed Yasser Habash, MD¹¹, Waleed Yasser Habash, MBBCh¹², Yousef Tanas, MBBCh¹, Yomna E. Dean, MBBCh¹, Walaa Hasan, MD¹³, Hani Aiash, MD, PhD^14
1Alexandria University, Alexandria, Al Iskandariyah, Egypt; ²American University of the Caribbean School of Medicine, St. Maarten, NY; ³Tanta University, Tanta, Asyut, Egypt; ⁴Assiut University, Asyut, Asyut, Egypt; ⁵Aleppo University, Aleppo, Halab, Syria; ⁶Ain Shams University, Ain Shams, Bani Suwayf, Egypt; ⁷Suez Canal University, Suez Canal, As Suways, Egypt; ⁸Arkansas College of Osteopathic Medicine, New York, NY; ⁹Aswan University, Aswan, Aswan, Egypt; ¹⁰Syracuse University, New York, NY; ¹¹Cairo University, Cairo, Al Qahirah, Egypt; ¹²New Giza University, Giza, Al Jizah, Egypt; ¹³Suez Canal University, Ismailia, Al Isma'iliyah, Egypt; ¹⁴Upstate Medical University, New York, NY

Introduction: Irritable bowel syndrome (IBS) seems to have an unclear pathogenesis in the majority of patients. Antibodies against gonadotropin-releasing hormone (GnRH) have previously been discovered in the blood of these patients on a significant occurrence. This meta- analysis aims to assess if there is a significant association between GnRH antibodies and IBS.

Methods: We defined a search strategy and implemented it to the PubMed, Ovid, Scopus and Web of Science databases for English language publications. The data were evaluated for acceptability, and controlled studies, either clinical trials, case control, cross sectional or cohort studies reporting the prevalence of GnRH antibodies in IBS patients were included. RevMan software version 5.4 was used for performing the analysis.

Results: The total number of patients in the included studies was 1095 (270 patients in the IBS group, and 825 patients in the control group). By comparing IBS group and control group, we found a statistically significant association between IBS and increased prevalence of GnRH IgM antibodies (RR = 2.29, 95% CI = 1.58 to 3.31, p-value < 0.0001). No heterogeneity was observed among studies (P = 0.20, I² = 36%). In GnRH receptor IGM antibodies outcome, we found a statistically significant association between IBS and increased prevalence of GnRH IgM antibodies compared with controls (RR = 3.80, 95% CI = 1.72 to 8.38, p-value = 0.0010). No heterogeneity was observed among studies (P = 0.85, I² = 0%). For GnRH receptor IgM antibodies, the pooled analysis showed a statistically significant association between IBS and increased prevalence of GnRH receptor IgM antibodies compared with controls (RR = 3.80, 95% CI = 1.72 to 8.38, P = 0.0010). No heterogeneity was observed among studies (P = 0.17, I² = 44%).

Discussion: This current meta-analysis revealed that GnRH IgM Antibodies may have an influence on the development of Irritable bowel syndrome, as Irritable bowel syndrome is related to a higher incidence of IgM antibodies against GnRH and its receptor when compared to healthy persons. More multicenter studies with higher sample sizes are needed to support our findings.


Disclosures:


Karam R.Motawea, ¹, Joseph Varney, MD², Mohamed Gamal, MBBCh³, Kirellos Said Abbas, MBBCh¹, Fatma Monib, MBBCh⁴, Sarya Swed, MBChB⁵, Sara Gebril, MBBCh⁶, Mohamed Kishk, MBBCh⁷, Hazem Dahshan, MBBCh⁷, Ibrahim Rakha, MBBCh⁷, Tharun Reddi, MBBCh⁸, Noheir Hassan, MD⁹, Aryan Arora, MD¹⁰, Mohamed Yasser Habash, MD¹¹, Waleed Yasser Habash, MBBCh¹², Yousef Tanas, MBBCh¹, Yomna E. Dean, MBBCh¹, Walaa Hasan, MD¹³, Hani Aiash, MD, PhD¹⁴. B0392 - Association of Irritable Bowel Syndrome and Antibodies Against Endogenous Gonadotropin-releasing Hormone and Its Receptor. a Systematic Review and Meta-analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.