A0472 - Sarcopenia Is a Risk Factor for Post-TIPS Hepatic Encephalopathy and Mortality: A Systematic Review and Meta-Analysis

Sunday, October 23, 2022

5:00 PM – 7:00 PM ET

Location: Crown Ballroom

Has Audio

Presenting Author(s)

Joyce Badal, PharmD

University of Toledo College of Medicine
Toledo, OH

Zohaib Ahmed, MD, MPH¹, Joyce Badal, PharmD², Ahmad Nawaz, MD³, Syeda F. Arif, ¹, Umer Farooq, MD⁴, Faisal Kamal, MD⁵, Toseed Javaid, MD¹, Muhammad Aziz, MD⁶, Anas Renno, MD⁷, Wade M. Lee-Smith, MLS¹, Asif Mahmood, MD¹, Ali Nawras, MD¹, Mona Hassan, MD⁸
¹University of Toledo, Toledo, OH; ²University of Toledo College of Medicine, Toledo, OH; ³Bridgeport Hospital, New Haven, CT; ⁴Loyola Medicine/MacNeal Hospital, Berwyn, IL; ⁵University of California, San Francisco, San Francisco, CA; ⁶The University of Toledo Medical Center, Toledo, OH; ⁷University of Toledo Medical Center, Toledo, OH; ⁸University of Toledo, Holland, OH

Introduction: TIPS is a commonly performed procedure in patients with liver cirrhosis to treat portal hypertension-related conditions, including refractory ascites and variceal bleeding. However, currently, there is no widely utilized method to predict those likely to develop
post-TIPS complications. Therefore, we conducted a systematic review and metaanalysis to evaluate Sarcopenia as a risk factor for post-TIPS hepatic encephalopathy and mortality.

Methods: A comprehensive search strategy was used to identify post-TIPS HE and post-TIPS mortality reports in Sarcopenia vs. non-sarcopenia patients with liver cirrhosis who received TIPS and was conducted till February 2022. Open Meta Analyst was used to compute the results.

Results: Nine studies, including 1439 patients, met our inclusion criteria and were included in the final meta-analysis. Sarcopenia was associated with significantly higher post-tips HE rate than non-sarcopenia (RR:1.68, CI: 1.33-1.989, p=0.001, I2=0%), as well
as a significantly higher post-TIPS mortality rate (RR: 1.75, CI:1.027-2.98, p=0.04, I2=86%).

Discussion: Our study found significant associations between Sarcopenia and increased rates of post-TIPS HE and mortality. To develop a reliable pre-procedure prognostic method to weigh the risks and benefits of TIPS in patients with cirrhosis, further studies are needed to determine the clinical relevance of important risk factors such as Sarcopenia on post-TIPS outcomes.

Disclosures:

Zohaib Ahmed indicated no relevant financial relationships.

Joyce Badal indicated no relevant financial relationships.

Ahmad Nawaz indicated no relevant financial relationships.

Syeda Arif indicated no relevant financial relationships.

Umer Farooq indicated no relevant financial relationships.

Faisal Kamal indicated no relevant financial relationships.

Toseed Javaid indicated no relevant financial relationships.

Muhammad Aziz indicated no relevant financial relationships.

Anas Renno indicated no relevant financial relationships.

Wade Lee-Smith indicated no relevant financial relationships.

Asif Mahmood indicated no relevant financial relationships.

Ali Nawras indicated no relevant financial relationships.

Mona Hassan indicated no relevant financial relationships.

Zohaib Ahmed, MD, MPH¹, Joyce Badal, PharmD², Ahmad Nawaz, MD³, Syeda F. Arif, ¹, Umer Farooq, MD⁴, Faisal Kamal, MD⁵, Toseed Javaid, MD¹, Muhammad Aziz, MD⁶, Anas Renno, MD⁷, Wade M. Lee-Smith, MLS¹, Asif Mahmood, MD¹, Ali Nawras, MD¹, Mona Hassan, MD⁸. A0472 - Sarcopenia Is a Risk Factor for Post-TIPS Hepatic Encephalopathy and Mortality: A Systematic Review and Meta-Analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.