C0529 - Diagnostic Performance of Contrast-Enhanced Ultrasound in Diagnosing Hepatic Artery Occlusion After Liver Transplantation: A Systematic Review and Meta-Analysis

Busara Songtanin, MD¹, Sebastian Sanchez, MD¹, Michelle Le, DO², Wuttiporn Manatsathit, MD^2
1Texas Tech University Health Sciences Center, Lubbock, TX; ²University of Nebraska Medical Center, Omaha, NE

Introduction: Evaluating the patency of hepatic artery after liver transplantation is crucial. Hepatic artery occlusion (HAO) is a common complication in liver transplant patients. Although clinical follow-up, CT angiography, surgery are considered the reference standard tests, but it is time-consuming and have significant costs. Contrast-enhanced ultrasound (CEUS) is the simple and less invasive procedure which can provide the visualization of hepatic artery with high accuracy. The aim of the study is to evaluate the performance of CEUS in detecting hepatic artery occlusion in liver transplant candidates.

Methods: We performed a systemic review and meta-analysis of studies evaluating the performance of CEUS for detection of HAO in adult population. A literature search of EMBASE, Scopus, Medline was performed through March 2022. Pooled sensitivity, specificity, and log diagnostic odd ratio (LDOR) were calculated. Publication bias was assessed by Deeks' funnel plot.

Results: Of the 134 studies identifed in our search, 8 studies meet our inclusion criteria. Total number of liver transplant participants in our study was 1,145 and CEUS was performed in 434 participants. Using CT angiography, follow-up, and surgery as the gold standard, the sensitivity, specificity, and LDOR of contrast-enhanced ultrasound for detection of HAO were 0.97(0.94–0.99), 0.99(0.98–1.00), and 5.73 (4.54-6.93). There was, however, significant publication bias (p=0.0139).

Discussion: Our analysis demonstrates that CEUS has excellent performance in detecting HAO after liver transplant. CEUS could be a reliable non-invasive alternative to diagnose HAO after liver transparent; however, there was potential publication bias.



Disclosures:


Busara Songtanin, MD¹, Sebastian Sanchez, MD¹, Michelle Le, DO², Wuttiporn Manatsathit, MD². C0529 - Diagnostic Performance of Contrast-Enhanced Ultrasound in Diagnosing Hepatic Artery Occlusion After Liver Transplantation: A Systematic Review and Meta-Analysis, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.