C0692 - Outcomes of Hospitalized Patients for Gastroparesis With History of Generalized Anxiety Disorder

Shivani J. Patel, MD¹, Alexander J. Kaye, MD, MBA¹, Sarah Meyers, DO², Anna G. Mathew, BA¹, Sushil Ahlawat, MD^1
1Rutgers New Jersey Medical School, Newark, NJ; ²Rutgers Robert Wood Johnson Medical School, Piscataway, NJ

Introduction: Gastroparesis is a disease of delayed gastric emptying with symptoms of early satiety, nausea, and vomiting. Common causes include diabetes mellitus, surgery, and viral infections. Anxiety disorders can have somatic aspects such as nausea and vomiting. Generalized anxiety disorder (GAD) is a prevalent anxiety disorder. This study investigates how a history of GAD impacts the outcomes of hospitalized patients with gastroparesis.

Methods: Using the 2014 National Inpatient Sample database, hospitalized patients with a diagnosis of gastroparesis were selected based on ICD-9 codes. Demographic data and outcomes were compared between hospitalized gastroparesis patients with GAD and without GAD. The outcomes assessed were inpatient mortality, perforation, obstruction, myocardial infarction (MI), hypotension/shock, hepatic failure, acute deep venous thrombosis (DVT), sepsis, respiratory failure, and acute renal failure (AKI). These outcomes were compared via chi-squared tests and independent t-tests. A multivariate logistic regression analysis was performed to assess if GAD is an independent predictor of the outcomes, after adjusting for age, sex, race, and Charlson Comorbidity Index (CCI).

Results: A total of 22,150 hospitalized patients with gastroparesis were identified during the year 2014. 4,196 had a comorbid diagnosis of GAD. Hospitalized patients with gastroparesis and GAD were noted to be younger (46.8 vs 48.1 years old, p< 0.001), more likely to be female (79.2% vs 66.1%, p< 0.001), more likely to be white (71.8% vs 55.9%, p< 0.001), had a lower CCI (2.25 vs 2.58, p< 0.001), and had an increased length of stay (4.7 vs 4.5 days, p=0.024). Total hospital charges were not significantly different (p=0.696) between patients with and without GAD. Notably, GAD is an independent risk factor for AKI (Adjusted odds ratio (aOR) 1.24, 95% confidence interval (CI) 1.11-1.39, p< 0.001). GAD was not found to be a risk factor for respiratory failure (p=0.583), sepsis (p=0.455), DVT (p=0.259), hypotension/shock (p=0.808), MI (p=0.256), obstruction (p=0.928), and inpatient mortality (p=0.476). Samples sizes for hepatic failure and perforation were too small to perform further analyses.

Discussion: This study demonstrated that GAD is an independent risk factor for AKI in adults hospitalized for gastroparesis. This finding may be attributed to increased severity of gastroparesis associated with anxiety, likely leading to poor oral intake and AKI.


Disclosures:


Shivani J. Patel, MD¹, Alexander J. Kaye, MD, MBA¹, Sarah Meyers, DO², Anna G. Mathew, BA¹, Sushil Ahlawat, MD¹. C0692 - Outcomes of Hospitalized Patients for Gastroparesis With History of Generalized Anxiety Disorder, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.