D0410 - Hodgkin’s Lymphoma in a Patient With Ulcerative Colitis: Case Presentation

Ismael P. Polo Perez, MD, Dailis B. Corria Cedeno, MD, Nabeel Sarhill, MD, Jason R. Phillips, MD
University of Texas Rio Grande Valley, Harlingen, TX

Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition characterized by relapsing and remitting episodes of inflammation limited to the colon's mucosal layer. Hodgkin lymphomas (HL) are lymphoid neoplasms of malignant cells admixed with a heterogeneous population of non-neoplastic inflammatory cells. Patients with autoimmune disorders are at increased risk for developing HL. Still, it is unclear if this is directly related to these conditions or to the immunosuppressive agents used to treat them.

Case Description/Methods: The case is a 36-year-old male patient diagnosed with UC in 2013 that was treated for four years with Humira and Prednisone with multiple episodes of relapsing. The patient presented numerous disease complications during this period, such as iron deficiency anemia. In January 2017, a follow-up colonoscopy reported pseudo polyps within the distal transverse colon and descending colon with active colitis in the sigmoid and rectum, with evidence of severe active colitis with some mass-like nodules. Due to these findings, the patient was evaluated for proctocolectomy, and plans were made for elective surgery. Before going for proctocolectomy, the patient received a diagnosis of lymphoma. In March 2017, the patient presented in the hospital with a history of more than one month of fever and generalized lymphadenopathies. After the lymph node biopsy, the patient was diagnosed with Hodgkin’s lymphoma III B. The patient was treated for HL with 12 cycles of combined chemotherapy (ABVD), tolerated the treatment, and achieved stable remission of HL and UC. He continues in remission after five years of follow-up. The last visit was in March 2022.

Discussion: The resolution of the UC during the treatment for HL results in an interesting benefit that doesn’t justify the chemotherapy for UC. Still, it is similar to the other few occasional cases in the literature.


Disclosures:


Ismael P. Polo Perez, MD, Dailis B. Corria Cedeno, MD, Nabeel Sarhill, MD, Jason R. Phillips, MD. D0410 - Hodgkin’s Lymphoma in a Patient With Ulcerative Colitis: Case Presentation, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.