E0380 - Impact of Inflammatory Bowel Disease on Outcomes of Patients Admitted With Pulmonary Embolism: A Nationwide Perspective

Mohammad Aldiabat, MBBS¹, Fnu Farukhuddin, MD², Yazan Aljabiri, MBBS³, Mubarak Yusuf, MD², Ali Horoub, MD², Yassine Kilani, MD³, Odai Alkhdour, MD⁴, Sura Issa, MD^5
1NYU Langone Hospital - Long Island, New York, NY; ²NYCHHC/Lincoln Medical Center, New York, NY; ³NYCHHC/Lincoln Medical Center, Bronx, NY; ⁴Yarmouk University, Irbid, Irbid, Jordan; ⁵The University of Jordan, New York, NY

Introduction: Inflammatory Bowel Disease (IBD) patients have an established higher risk of Venous Thromboembolism, including Pulmonary Embolism (PE), secondary to chronic inflammatory state. However, Impact of IBD on the prognosis of admitted PE patients remains unstudied. Therefore, authors aim to investigate outcomes of hospitalized PE patients in the setting of IBD.

Methods: Using International Classification of Diseases Tenth Revision (ICD-10) codes, the National Inpatient Sample database of the years 2016 to 2019 was searched for patients admitted with a primary diagnosis of PE, with and without a past medical history of IBD listed as secondary diagnosis. Univariate and Multivariate logistic regression analysis was performed to determine the risk of mortality and in-hospital complications in PE/IBD group compared to PE/non-IBD group. Baseline patients and facilities characteristics were incorporated into the analysis. Data was considered statistically significant if p-value was < 0.05.

Results: Among 750,654 adults’ patients who were hospitalized in US with a primary diagnosis of PE from 2016 - 2019, 6,995 (1%) had a secondary diagnosis of IBD. Patients baseline characteristics are listed in Table 1. After running multivariate regression analysis, history of IBD was not associated with mortality difference in PE patients (aOR 0.80, p=0.245). In term of in-hospital outcomes (Figure 1), IBD/PE patients had an increased risk of cardiac arrythmias (aOR 1.18, p= 0.035) and sepsis (aOR 1.37, p=0.048), with no significant difference in risk of acute kidney injury (aOR 1.01, p=0.882), septic shock (aOR 1.28, p=0.516), acute coronary syndrome (aOR 0.83, p=0.337), acute respiratory failure (aOR 0.92, p=0.244) and in-hospital cardiac arrest (aOR 2.24, p=0.319). IBD/PE group had a prolonged length of stay (aMD 0.56 days, p=< 0.001) and increased cost of care (aMD 4093$, p=0.023) when compared to admitted PE patients who are IBD-free.

Discussion: Our study demonstrates that patients with PE have a slightly worse in-hospital outcomes in the setting of IBD, represented by increased risk of sepsis and cardiac arrythmias, and prolonged length of stay and healthcare resources utilizations. Further studies are needed to validate our findings, to prompt proper risk satisfaction and for IBD patients who are admitted with PE in a goal to reduce the incidence of the before mentioned outcomes and to reduce healthcare resources utilization in this group of patients.




Disclosures:


Mohammad Aldiabat, MBBS¹, Fnu Farukhuddin, MD², Yazan Aljabiri, MBBS³, Mubarak Yusuf, MD², Ali Horoub, MD², Yassine Kilani, MD³, Odai Alkhdour, MD⁴, Sura Issa, MD⁵. E0380 - Impact of Inflammatory Bowel Disease on Outcomes of Patients Admitted With Pulmonary Embolism: A Nationwide Perspective, ACG 2022 Annual Scientific Meeting Abstracts. Charlotte, NC: American College of Gastroenterology.