Complexities of Bilateral Odontogenic Cyst Pathology in Pediatric Patients
Sunday, May 1, 2022
Location: Sails Pavilion
Noonan Syndrome is a common genetic disorder that causes multiple abnormalities including congenital heart disease, failure to thrive, short stature, developmental delays and renal malformation. Cherubism and central giant cell granuloma (CGCG) have overlapping physical manifestations. Patients with either disease have cystic lesions developing in the jaw and/or maxilla. Cherubism is however an autosomal dominant hereditary disease that affects the SH3BP2 gene. Histologically, CGCG is distinguishable from Cherubism. Genetic testing, clinical signs, radiographic signs, histology and molecular examinations together with family history can allow for the proper diagnosis. Patients that have multiple diseases and syndromes make diagnosis difficult without proper biopsies. The following report reviews the background of cherubism, Noonan syndrome and CGCG and proper considerations to take care of pediatric patients affected.
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