Prevalence of Hypogonadism and its Relation with Glycemic Control in Young Adults with Chronic Type 2 Diabetes Mellitus

There is an increased prevalence of hypogonadism in type 2 diabetes mellitus our study was aimed at to study the prevalence of hypogonadism in young adults with chronic type 2 diabetes mellitus.

Methods:

In this cross-sectional study 260 patients from 3 different cities of India were included between age group 30-39 with history of type 2 diabetes mellitus. Patients were divided into 2 groups, group A (130 patients) with history of type 2 diabetes mellitus more than 6 years and group B (130 patients) with history of type 2 diabetes less than 6 years.

Levels of hypogonadism and erectile dysfunction was compared between 2 groups on the basis parameters of Total Testosterone values and ADAMS questionnaire, glycemic parameters were measured on the basis of HbA1c. One-way ANOVA followed by post hoc Tukey's test and Pearson's coefficient of correlation tests were used for analysis. Hypogonadism was measured with levels of total testosterone less than 250.

Results:

• Mean HbA1c levels of group A was 8.12% and group B was 8.09%
• 9 patients opted out of the study due to non-consent, 5patients from group A and 4 patients from group B
• Hypogonadism TT < 250 was observed in 25.6% of males (32/125) in group A as compared to 10% of males (13/126) in group B
• Prevalence of erectile dysfunction was observed in 54.4% of males (68/125) in group A as compared to 31.74 % in males (40/126) in group B
• Higher degree of low testosterone was observed in group A with chronic history of type 2 diabetes as compared to group B, prevalence of erectile dysfunction in group A was non-significantly higher as compared to group B
• An overall positive correlation was found between levels of hypogonadism and chronic history of type 2 diabetes

We observed hypogonadism as indicated in significant proportion of males with chronic history of type 2 diabetes mellitus.