Director Indiana Center for Regenerative Medicine & Engineering Indianapolis, IN
There are only a few (FDA)-approved treatments for chronic wounds, largely due to an incomplete understanding of chronic wound pathophysiology in humans. Understanding the metabolic and molecular processes that lead to chronic wound pathology is paramount to identifying optimal treatment options. Discussion will include chronic wound samples subjected to analyses correlating histopathology, RNA-Sequencing, and immunohistochemistry of selected protein markers representing 3 areas of chronic wound biology: inflammation, vascularization and re-epithelialization. We reveal that distinct gene expression patterns exist between the wound sub-regions, which can be utilized for wound assessments.