Participants should be aware of the following financial/non-financial relationships: . Karen Raju, BDS, MPH, DPH-C: I do not have any relevant financial / non-financial relationships with any proprietary interests.. Israel Terungwa Agaku, PhD: I do not have any relevant financial / non-financial relationships with any proprietary interests.
Abstract: Objectives: To describe the prevalence of periodontitis and DM among marijuana users and examine the effect of marijuana on the relationship between periodontitis and DM status in US adults aged 30-59 years. Methods: Pooled data from the National Health and Nutrition Examination Survey(NHANES) 2009-2014 were analyzed. The primary binary outcome was self-reported diabetes mellitus(DM). Exposure of interest (periodontitis) was defined using the Centers for Disease Control and Prevention/American Academy of Periodontology classification. Regular marijuana users were those who had ever smoked marijuana at least once a month for more than one year. Bivariate and multivariable binary logistic regression models were performed to examine the effect of marijuana on the relationship between periodontitis and DM. Results: Of 3,179 non-pregnant participants with available periodontitis, DM, and marijuana use, 85.5% were regular marijuana users. Moderate(OR 2.07;1.65,2.61) and severe(OR 3.24;2.48,4.24) periodontitis was significantly associated with marijuana use. No statistically significant difference between the prevalence of DM among marijuana users(P=0.14). Bivariate analysis revealed a positive association between periodontitis and DM irrespective of marijuana use. The fitted multivariable model retained this association. The increasing age, being non-Hispanic whites (aOR 0.36; 0.19,0.67), having Medicaid (aOR 3.04;1.52,6.10), and Medicare insurance (aOR3.87;2.00,7.49) significantly predicts DM. Conclusions: Moderate and severe periodontitis is associated with marijuana use. Periodontitis is associated with DM in both Marijuana users and non-users. However, readers should use the results of this study with caution, and further high-quality longitudinal studies are required to elucidate the effect of marijuana on the relationship between periodontitis and DM.
