Collaborative Researcher Tokyo University of Agriculture and Technology Fuchu, Tokyo, Japan
Midterm Change in Renin-Angiotensin-Aldosterone System Profile Along the Course of Cardiac Reverse Remodeling Process After Mitral Valvuloplasty in Dogs. Cheng CJ1–3, Mandour A2;4, Yoshida T3;6, Watari T5, Tanaka R6, Matsuura K2;3. 1Nihon University, Laboratory of Veterinary Internal Medicine, Fujisawa, Japan; 2Tokyo University of Agriculture and Technology, Veterinary Surgery, Fuchu, Japan; 3VCA Japan Shiraishi Animal Hospital, Sayama, Japan; 4Suez Canal University, Veterinary Internal Medicine, Ismailia, Egypt; 5Nihon University, Fujisawa, Japan; 6Tokyo University of Agriculture and Technology, Fuchu, Japan. Information regarding changes in renin-angiotensin-aldosterone system (RAAS) characteristics along cardiac reverse remodeling after mitral valvuloplasty (MVP) in dogs remains lacking. This study aims to assess longitudinally the midterm effect of MVP on RAAS activity. Eight client-owned dogs receiving MVP for myxomatous mitral valve disease (MMVD) were enrolled and closely monitored for plasma renin activity (PRA), angiotensin II (AT2), aldosterone (PAC), blood urea nitrogen (BUN), and creatinine concentrations, concomitantly with echocardiography before (baseline) and at three consecutive monthly follow-ups (post-1 mo., post-2 mo., post-3 mo.) after MVP. The echocardiography revealed a significant decrease in LVIDDN, LA/Ao, FS, E velocity, E/A, E' sep, S' lat, E' lat, and A' lat after MVP compared with baseline (P < 0.05). Also, there was a significant associated reduction in the medians of PRA (2.74, 3.05, 2.45 vs. 8.8 ng/mL/hr; P = 0.0039), AT2 (235, 315, 466 vs. 1200 pg/mL; P = 0.0068), and PAC (54.62, 47, 39.88 vs. 179.5 pg/mL; P = 0.0017), respectively at post-3 mo., post-2 mo., post-1 mo., compared with the baseline. Additionally, plasma BUN and creatinine levels were significantly decreased after MVP. The RAAS trend was significantly correlated with selected echocardiographic parameters. Main limitations include the small number and heterogeneity in characteristics of animals enrolled and rather incomprehensive and short-term documentation of RAAS. The present study demonstrated mid-term down-regulatory effects of MVP on the RAAS in MMVD dogs, which paralleled the process of cardiac reverse remodeling up to postoperative third month. This information facilitates formulating strategies to optimize clinical outcomes for the post-MVP canine population.