P1293 - Cutaneous Metastasis From Colon Cancer

Megan Richardson, MD¹, Joe Nenow, MD², Adrian Pona, MD², Karissa Lambert, MD^2
1none, Waterdown, ON, Canada; ²East Carolina University, Greenville, NC

Introduction: Since cutaneous metastasis from colon cancer is rare, the basic morphology and distribution are not well known. The purpose of this study was to evaluate the clinical features designed to better characterize the clinical characteristics of cutaneous metastasis from colon cancer.

Methods: A Pubmed search using the search term “cutaneous metastasis colon cancer” was conducted with 145 total results, of which 52 were relevant and “cutaneous metastasis colon adenocarcinoma” with 95 results, of which many were repeated from previous search, with 2 more relevant articles. Inclusion criteria: skin biopsy to confirm metastasis and cutaneous findings, English language. Gender, age, morphology, and distribution of lesions were included in the study.

Results: The total number of patients in this study was 60. The total age of patients ranged from 35-92, with a mean of 65.13. Males ranged from 35-86, with female ages ranging from 35-92. Males accounted for 55% of patients, females 43% and 2% of patients with unknown gender.

When reported in percentage relative to category total the following results were obtained. When categorized by pain, 38% were tender and 63% were non-tender. When categorized by colour, 38% were flesh-coloured, 24% were pink-red or hyper pigmented and 14% were white. When categorized by lesion category, 38% were nodular, 37% were masses, 12% were plaques, 9% were papule and 4% were cyst-like.

When reported as percentage relative to total number of skin findings, in descending order: nodule 36%, masses 34%, firm consistency 33%, erythema 19%, multiple skin lesions 19%, previous trauma 18%, induration 11%, flesh-coloured 11%, skin degradation 11%, plaques 11%, irregular margins 10%, papule 8%, well-defined 8%, multi-coccoid 8%, non-tender 7%, pink-red 7%, hyper pigmented 7%, ovoidal 5%, exophytic 5%, tender 4%, white 4%, and cyst-like 4%.

The distribution of lesions reported as a percentage of total lesions in descending order: head 27%, abdomen 17%, back 16%, chest 14%, groin 11%, thighs 6%, axilla 5%, and hand 2%.

Discussion: There have been few reported cases of cutaneous metastasis of colon cancer. By understanding the morphology and demographics of patients that have presented with cutaneous metastasis of colon cancer it could make the identification process easier. It is important for gastroenterologists to consider skin lesions as possible metastasis of patients with colon cancer or previously diagnosed colon cancer.


Disclosures:


Megan Richardson, MD¹, Joe Nenow, MD², Adrian Pona, MD², Karissa Lambert, MD². P1293 - Cutaneous Metastasis From Colon Cancer, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.