Alexander Hooper, MD1, Eric Pasman, MD2, Steve B. Min, MD3, Fouad J. Moawad, MD4 1Scripps Clinic, La Jolla, CA; 2Naval Medical Center San Diego, San Diego, CA; 3Walter Reed National Military Medical Center, North Potomac, MD; 4Scripps Clinic, San Diego, CA
Introduction: Eosinophilic esophagitis (EoE) is a significant cause of dysphagia and food impactions. The clinical symptoms of EoE are likely secondary to tissue remodeling and fibrosis. Endoscopists have long appreciated a firmness of the esophageal mucosa when obtaining EoE biopsies, referred to as the “tug” or “pull” sign. Quantitative measurements have recently been recorded in pediatric patients but not in the adult population. We seek to measure the quantifiable difference in force required to obtain esophageal biopsies in adult patients with and without EoE.
Methods: Patients undergoing esophagogastroduodenoscopy (EGD) for a history of or suspected EoE were enrolled. During endoscopy, a screw compressor clamp was attached at the most distal positioning marker of a 2.8 mm radial jaw forceps (Boston Scientific). The clamp provided a stable position to attach a Newton force gauge (Nidec-Shimpo FG-3006). Maximum forces required to obtain up to 8 esophageal biopsies from the proximal half and distal half of the esophagus were measured, from which mean force and peak force per patient were calculated. Total eosinophil counts per high power field (eos/hpf) and Eosinophilic Esophagitis Endoscopic Reference Score (EREFS) were obtained.
Results: At total of 31 patients were enrolled (20 EoE; 11 controls). EoE patients were more likely to be younger males with a history of food allergies and eczema. Patients with EoE showed a significant increase in both mean force (9.3N +/- 2.6 vs 6.5N +/- 1.8, p=0.002) and peak force (13.7N +/- 3.8 vs 9.0N +/- 2.7, p< 0.001). The optimal peak force that suggests a patient has EoE was 10.6N (Sen 0.90, Spec 0.91, AUC 0.89) by Youden index. There was a positive correlation between peak force and increased EREFS, but no observed correlation between specific number of eos/hpf with peak force.
Discussion: We showed that obtaining biopsies from adult EoE patients requires significantly more force compared to non-EoE controls, confirming the previously noted “tug” or “pull” sign. Measuring a peak force appears to be both sensitive and specific for the identification of EoE. The association between the peak force and EREFS suggests a potential correlation with fibrosis. Ultimately, the measurement of tensile force could serve as an additional tool in the diagnosis, prognosis and management of EoE.
Disclosures:
Alexander Hooper indicated no relevant financial relationships.
Eric Pasman indicated no relevant financial relationships.
Steve Min indicated no relevant financial relationships.
Fouad Moawad indicated no relevant financial relationships.
Alexander Hooper, MD1, Eric Pasman, MD2, Steve B. Min, MD3, Fouad J. Moawad, MD4. P2384 - Quantitative Analysis of the Tug Sign in Adults: An Endoscopic Finding of Eosinophilic Esophagitis, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.