P2476 - Prospective Evaluation of Gastrointestinal Symptoms and Health-Related Quality of Life in Patients With Postural Orthostatic Tachycardia Syndrome Using Validated Surveys

Ibrahim Abboud, ¹, Yazan Abboud, MD², Brent Hiramoto, MD³, Rusha Modi, MD¹, Laurie D. DeLeve, MD¹, Sonia Taneja, MD¹, Jennifer L. Dodge, MPH⁴, Edy Soffer, MD¹, Anisa Shaker, MD^1
1Keck School of Medicine of the University of Southern California, Los Angeles, CA; ²Cedars-Sinai Medical Center, Los Angeles, CA; ³Keck School of Medicine of the University of Southern California, Los Angeles, CA; ⁴University of Southern California, Monterey, CA

Introduction: Patients with Postural Orthostatic Tachycardia Syndrome (POTS) often report gastrointestinal (GI) symptoms and comorbid joint hypermobility/Ehlers-Danlos-Syndrome (EDS). Yet, GI symptoms and quality of life (QOL) have not been fully described. We aimed to characterize GI symptoms and QOL in patients with POTS and assess differences by EDS.

Methods: Patients with suspected POTS presenting to a tertiary medical center GI Division were prospectively administered validated surveys to quantify GI symptoms and QOL. Electronic chart review confirmed POTS and EDS diagnoses. GI symptoms were measured by (1) Patient-Reported Outcomes Measurement Information System (PROMIS) GI symptom scales, (2) GERDQ, and (3) Gastroparesis Cardinal Symptom Index (GCSI) with higher scores indicating worse symptoms. QOL was measured by 8 SF-36 domains with higher scores reflecting a more favorable health state and compared to published general population scores. Scores were summarized as means (±SD) and compared by presence vs absence of EDS using the t-test and bivariate linear regression adjusting for age.

Results: Of 21 patients administered surveys (95% completion rate), POTS was confirmed in 18 (all female, mean age 34 ±11.9 years), 11 of whom had EDS (61%) (Table). Mean PROMIS T scores were >50 (general population average) for all GI scales reflecting worse symptoms vs the general population with scores highest for belly pain, gas/bloating, and disrupted swallowing and lowest for diarrhea. Mean SF-36 scores were lower vs the general population for all 8 domains reflecting lower QOL with scores lowest for physical limitations and highest for emotional well-being. POTS+EDS patients were younger than without EDS (mean age 30 (±8.7) vs 42 (±13.1) years, p=0.03). Mean PROMIS bowel incontinence symptoms were worse for POTS without vs with EDS (6.4 (±2.9) vs 4.2 (±0.6), p=0.02) but not after age adjustment (p=0.18). Other GI symptoms were similar. QOL was similar except SF-36 bodily pain was worse in POTS with vs without EDS (22.3 (±18.3) vs 46.8 (±22.6), p=0.02) and remained a mean of 22.9 points lower (p=0.06) after age adjustment. Mean GI symptom and QOL scales were worse than the general population regardless of EDS.

Discussion: In our cohort of POTS patients, GI symptoms and QOL were worse compared to the general population. POTS+EDS patients were younger and reported worse bodily pain than those without EDS. Surveys are ongoing to identify additional comorbidities and predictors of GI symptoms and QOL.



Disclosures:


Ibrahim Abboud, ¹, Yazan Abboud, MD², Brent Hiramoto, MD³, Rusha Modi, MD¹, Laurie D. DeLeve, MD¹, Sonia Taneja, MD¹, Jennifer L. Dodge, MPH⁴, Edy Soffer, MD¹, Anisa Shaker, MD¹. P2476 - Prospective Evaluation of Gastrointestinal Symptoms and Health-Related Quality of Life in Patients With Postural Orthostatic Tachycardia Syndrome Using Validated Surveys, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.