University Hospitals Case Medical Center, Case Western Reserve University Cleveland, OH, United States
Vijit Chouhan, MD1, Emad Mansoor, MD1, Jit Patel, MD1, Gregory Cooper, MD2 1University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH; 2University Hospitals Case Medical Center, Cleveland, OH
Introduction: There is a paucity of literature investigating the prevalence of Helicobacter Pylori (HP) infection in patients with diabetes mellitus (DM) versus patients without DM. We described the epidemiology of HP in DM in the United States utilizing a large, population-based database.
Methods: We queried the Explorys database (Cleveland, OH), and identified patients with HP and DM and HP without DM between 2015 and 2020. We calculated the prevalence of HP in DM among different patient groups and identified risk factors for HP occurrence in DM.
Results: HP in DM was more prevalent in non-elderly, females, and Caucasians compared to elderly, males, and African Americans. The occurrence of HP was also increased in patients with DM in addition to other specific risk factors.
Discussion: HP in DM is increased in specific patient groups including non-elderly, females, and Caucasians and specific risk factors are also associated with an increased prevalence. There should be a lower threshold for investigation of HP in patients with DM depending on clinical presentation and past medical history.
Figure: Figure 1. Prevalence of Helicobacter Pylori (HP) in Diabetes Mellitus (DM) vs Non-DM According to Age, Gender, and Race
Risk Factor
Odds Ratio (95% Confidence Interval)
p-value
Tobacco abuse
1.94 (1.62-2.33)
p< 0.05
Alcohol abuse
2.04 (1.48-2.80)
p< 0.05
NSAID use
39.9 (31.21-51.19)
p< 0.05
Family History of Cancer
2.82 (2.32-3.43)
p< 0.05
Insulin use
1.19 (1.02-1.38)
p< 0.05
Cardiovascular Disease
84.20 (63.13-112.30)
p< 0.05
PPI use
7.16 (5.91-8.67)
p< 0.05
Probiotic use
1.24 (0.66-2.32)
p=0.48
Obesity
2.13 (1.83-2.47)
p< 0.05
Table: Table 1. Odds Ratios for Traditional Risk Factors of Helicobacter Pylori Infection in Diabetes in the United States Between 2016 and 2021.
Disclosures:
Vijit Chouhan indicated no relevant financial relationships.
Emad Mansoor indicated no relevant financial relationships.
Jit Patel indicated no relevant financial relationships.
Gregory Cooper indicated no relevant financial relationships.
Vijit Chouhan, MD1, Emad Mansoor, MD1, Jit Patel, MD1, Gregory Cooper, MD2. P3068 - Prevalence of Helicobacter pylori in Diabetes Mellitus in the United States: A National Population-Based Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.
