P2844 - Prevalence of Hyperthyroidism in Patients With Non-Alcoholic Fatty Liver Disease: A Population-Based Study

Ashraf Momani, MD¹, Ashraf Almomani, MD², Motasem Alkhayyat, MD², Mohannad Abou-Saleh, MD², Emad Mansoor, MD³, Adrian Lindsey, MD^3
1Cleveland Clinic Foundation, Fairview Park, OH; ²Cleveland Clinic Foundation, Cleveland, OH; ³Case Western Reserve University, Rocky River, OH

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently considered as the most common cause of chronic liver disease worldwide. Risk factors for NAFLD have been well-described, including obesity, type 2 diabetes mellitus (T2DM), dyslipidemia (DLP) and metabolic syndrome. While hypothyroidism has been identified as an independent risk factor for the development of NAFLD, the presence of hyperthyroidism has not been previously explored. Our aim is to evaluate the prevalence of hyperthyroidism in patients with NAFLD and to assess if it is an independent risk factor.

Methods: Our cohort’s data was obtained using a validated, large, multicenter database (Explorys Inc, Cleveland, OH, USA) aggregated from pooled outpatient and inpatient records of 26 different healthcare systems, consisting of a total of 360 hospitals in the United States, and utilizing Systematized Nomenclature of Medicine-Clinical Terms for coding. We evaluated a cohort of patients with hyperthyroidism and NAFLD. Multivariate analysis was performed to adjust for confounding risk factors including HTN, T2DM, DLP, obesity and metabolic syndrome. Statistical Package for Social Sciences (SPSS version 25, IBM Corp) was used for statistical analysis, and for all analyses a 2-sided p-value of < 0.05 was considered statistically significant. Exclusion criteria was limited to age < 18 years.

Results: Among the 37,648,180 included individuals in this database who were above the age of 18 years, there were a total of 2320 patients with NAFLD (6.16 per 100,000) in the last five years (2015-2020), amongst which 50 patients (2.2%) had hyperthyroidism. Baseline characteristics of patients in this database are described in Table 1. Patients with NAFLD were more likely to have obesity, T2DM, DLP, HTN and metabolic syndrome, as is well documented in the literature. While males and females were equally affected, patients in the age group 18-65 years as well as Caucasians seem to be at a higher risk. Interestingly, there was a positive correlation between patients with NAFLD and hyperthyroidism, independent of the other risk factors (odds ratio 2.536) (Table 2).

Discussion: Hyperthyroidism has a positive correlation with NAFLD, suggesting it is an independent risk factor for the development of NAFLD similar to its counterpart, hypothyroidism. Further studies are needed to delineate and confirm the causative relationship between hyperthyroidism and NAFLD.




Disclosures:


Ashraf Momani, MD¹, Ashraf Almomani, MD², Motasem Alkhayyat, MD², Mohannad Abou-Saleh, MD², Emad Mansoor, MD³, Adrian Lindsey, MD³. P2844 - Prevalence of Hyperthyroidism in Patients With Non-Alcoholic Fatty Liver Disease: A Population-Based Study, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.