P1176 - Prognostic Value of NOTCH1 in Colorectal Adenocarcinoma

Monday, October 25, 2021

10:30 AM – 4:15 PM PT

Location: Shoreline Exhibit Hall

Has Audio

Presenting Author(s)

Chenyu Sun, MD, MSc

AMITA Health Saint Joseph Hospital
Chicago, IL, United States

Chenyu Sun, MD, MSc¹, Shaodi Ma, ², Yue Chen, ³, Chandur Bhan, MD¹, Sudha Misra, MD¹, Na Hyun Kim, MD¹, John Pocholo W. Tuason, MD¹, Yasmin A. Gerais, MD¹, Mohamed R. Ismail, MBBCh¹, Yuting Huang, MD, PhD⁴
¹AMITA Health Saint Joseph Hospital, Chicago, IL; ²School of Public Health, Anhui Medical University, Hefei, Anhui, China; ³School of the First Clinical Medicine, Anhui Medical University, Hefei, Anhui, China; ⁴University of Maryland Medical Center Midtown Campus, Baltimore, MD

Introduction: Colorectal adenocarcinoma (COAD) is a common gastrointestinal cancer. The aim of this study was to identify the protein with a worse prognosis of COAD.

Methods: The TRGAted platform (https://nborcherding.shinyapps.io/TRGAted/), is a web tool for survival analysis based on Reverse-phase protein array (RPPA) data retrieved from The Cancer Genome Atlas (TCGA). The protein with the highest hazard ratio (HR) of COAD was selected, for further survival analysis, between high and low expression groups. The optimal cutoff was determined based on the surv-cutpoint function in the survminer package via TRGAted. HR was determined by the Cox proportional hazard regression model.

Results: NOTCH1 was found to have the highest HR of 4.76 (P=0.0035) and was then selected. Subgroup analysis found a statically significant worse survival for adenocarcinoma (HR=6.37, P=0.0031) and nonsignificant change for mucinous adenocarcinoma (HR=0.253, P=0.08). For different age groups, NOTCH1 was associated with a worse poor prognosis (HR4.14, P=0.009) for patients age 51-90, while for patients age 31-50, NOTCH1 was associated with improved survival (HR 0.131, P=0.029).

Discussion: NOTCH1 is overall associated with poor prognosis of COAD, however, for mucinous adenocarcinoma, it was not associated with the change of survival. For patients age 51 and above, it is associated with a poor survival rate, but interestingly for the younger group of age 31-50, it is associated with improved prognosis.

Figure: A) NOTCH1 is associated with worst prognosis; B) subgroup analysis of mucinous adenocarcinoma and adenocarcinoma; C) Subgroup analysis of different age groups

Disclosures:

Chenyu Sun indicated no relevant financial relationships.

Shaodi Ma indicated no relevant financial relationships.

Yue Chen indicated no relevant financial relationships.

Chandur Bhan indicated no relevant financial relationships.

Sudha Misra indicated no relevant financial relationships.

Na Hyun Kim indicated no relevant financial relationships.

John Pocholo Tuason indicated no relevant financial relationships.

Yasmin Gerais indicated no relevant financial relationships.

Mohamed Ismail indicated no relevant financial relationships.

Yuting Huang indicated no relevant financial relationships.

Chenyu Sun, MD, MSc¹, Shaodi Ma, ², Yue Chen, ³, Chandur Bhan, MD¹, Sudha Misra, MD¹, Na Hyun Kim, MD¹, John Pocholo W. Tuason, MD¹, Yasmin A. Gerais, MD¹, Mohamed R. Ismail, MBBCh¹, Yuting Huang, MD, PhD⁴. P1176 - Prognostic Value of NOTCH1 in Colorectal Adenocarcinoma, ACG 2021 Annual Scientific Meeting Abstracts. Las Vegas, Nevada: American College of Gastroenterology.